负载活性药物的聚β-羟基丁酸酯涂层对Mg-4.1Y-2.8Nd-0.2Zn-0.4Zr合金在模拟体液中降解行为和对细胞功能的影响  

Effects of Drug-contained Poly-β-hydroxybutyrate Coating on Degradation Behavior of Mg-4.1Y-2.8Nd-0.2Zn-0.4Zr Alloy in Simulated Body Fluid and Cell Function

作　　者：全亮 葛淑萍 贾东煜[3] 刘陈宇 王贵学 尹铁英[2] Quan Liang;Ge Shuping;Jia Dongyu;Liu Chenyu;Wang Guixue;Yin Tieying(Chongqing University of Technology,Chongqing 400054,China;Key Laboratory of Biorheological Science and Technology,Chongqing University,Chongqing 400044,China;Georgia Southern University,Georgia GA 30460,USA)

机构地区：[1]重庆理工大学,重庆400054 [2]重庆大学生物流变科学技术重点实验室,重庆400044 [3]乔治亚南方大学,美国乔治亚州GA 30460

出　　处：《稀有金属材料与工程》2020年第8期2599-2606,共8页Rare Metal Materials and Engineering

基　　金：National Natural Science Foundation of China(31700826);Chongqing Research Program of Basic Research and Frontier Technology(cstc2017jcyj AX0284);Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology(Chongqing University),Ministry of Education(CQKLBST-2016-001)。

摘　　要：镁及其合金作为可吸收生物材料在临床医学中具有巨大潜力,但其过快的腐蚀速率可能会导致植入失效。通过使用层-层自组装技术在WE镁合金表面制备一种带有生物活性药物的聚β-羟基丁酸酯(PHB)复合涂层对镁合金的耐降解性能进行改善,并对具有该药物涂层的镁合金在模拟体液(SBF)中的降解行为以及在降解期间溶液中的离子浓度和微观结构的变化进行观察。通过细胞迁移,细胞毒性和细胞凋亡来研究药物涂层对细胞以及组织的影响。结果表明,该活性药物涂层有效降低了样品在SBF中的腐蚀速率,细胞毒性以及细胞凋亡率,并促进了细胞在材料表面的迁移。Magnesium and its alloys have great potential as absorbable biomaterials in clinical medicine,but their rapid corrosion might lead to implant failure.Poly-β-hydroxybutyrate(PHB)coating with drug was prepared on the surface of WE magnesium alloys using layer-by-layer self-assembly technique.The corrosion behavior of magnesium alloys with drug coating in simulated body fluid(SBF)was studied.The solution concentration and microstructure change during degradation process were observed.The effects of drug coating on tissue cells were investigated by cell migration,cytotoxicity and apoptosis.The results show that the bioactive drug coating effectively reduces the corrosion rate of the samples in SBF,cytotoxicity,apoptosis,and promotes the migration of the cells.

关 键 词：镁合金 生物材料 PHB 细胞 降解 

分 类 号：R318.08[医药卫生—生物医学工程]