小胶质细胞对创伤性脑损伤病理生理影响的研究进展  

Research advances in effect of microglia on pathophysiology following traumatic brain injury

作　　者：马羽霄 杨春[1] 冯军峰[1] Ma Yuxiao;Yang Chun;Feng Junfeng(Department of Neurosurgery,Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Head Trauma,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院神经外科,上海市颅脑创伤研究所,200127

出　　处：《中华创伤杂志》2020年第8期743-748,共6页Chinese Journal of Trauma

基　　金：国家自然科学基金(81771317,31371406);上海市人才发展资金(2018077)。

摘　　要：小胶质细胞是中枢神经系统的免疫细胞,生理状态下小胶质细胞在神经系统的监控、诱导凋亡及突触的成熟等方面具有重要作用。创伤性脑损伤(TBI)作为一种病理损害可以引起中枢神经系统结构和功能损伤,而激活的小胶质细胞能够改变其病理进程,在损伤的过程中发挥重要功能。笔者就小胶质细胞的生理功能及其在TBI后的病理作用作一综述,为TBI的临床治疗提供借鉴。Microglia are the immune cells in central neural system.Microglia play an important role in central neural system such as surrounding environment monitoring,apoptosis induction and mature synapse formation.Besides,as a pathological process,traumatic brain injury(TBI)can cause the structure and function damage of central nervous system.While the activated microglia can change the TBI-induced pathological process and play an important role during the course of injury.Therefore,the authors review the important physiological function of microglia and its pathological role so as to provide references for clinical treatment.

关 键 词：脑损伤 细胞生理过程 预后 

分 类 号：R651.15[医药卫生—外科学]