双胎妊娠并发子痫前期临床研究进展  

Clinical research progress of twin pregnancy with preeclampsia

作　　者：刘巧凤 刘兆董 李仁善 陈泓儒 林俊伟 陈岩[1] Liu Qiaofeng;Liu Zhaodong;Li Renshan;Chen Hongru;Lin Junwei;Chen Yan(Fujian Medical University,Fuzhou 350004,China;Department of Gynecology and Obstetrics,Fujian Maternity and Child Health Hospital&Teaching Hospital of Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建医科大学,福州350004 [2]福建省妇幼保健院,福建医科大学教学医院妇产科,福州350001

出　　处：《中国综合临床》2020年第5期413-416,共4页Clinical Medicine of China

基　　金：福建医科大学大学生创新创业训练计划资助项目(L19016);福建省妇幼保健院科技创新启动基金(妇幼YCXM 18-28)。

摘　　要：子痫前期是产科特发的多系统疾病,常导致不良妊娠结局。双胎妊娠为高危妊娠,发生子痫前期时病情重,母儿并发症增加,其临床诊治研究越来越受到临床医师重视。子痫前期的发病机制多样化,双绒毛膜性、辅助生殖技术受孕、初产妇、高龄等均为双胎妊娠并发子痫前期的高危因素;终止妊娠时机根据绒毛膜性来选择,可适当放宽剖宫产指征,以减少母儿不良妊娠结局。临床研究多是利用综合指标联合筛查的方式预测子痫前期,如何药物预防仍需进一步的临床及基础研究。Preeclampsia is a multiple system disease in obstetrics,which often leads to adverse pregnancy outcome.Twin pregnancy is a high-risk pregnancy.When preeclampsia occurs,the condition is very serious,and the complications of mother and child are increasing.The pathogenesis of preeclampsia is diversified.The high risk factors of twin pregnancy with preeclampsia are bichorionic,assisted reproductive technology pregnancy,primipara,and advanced age.The timing of termination of pregnancy should be selected according to chorionic nature,and the indications of cesarean section should be relaxed to reduce the adverse pregnancy outcomes.Clinical studies mostly use comprehensive indicators combined with screening to predict preeclampsia.How to prevent preeclampsia still needs further clinical and basic research.

关 键 词：双胎妊娠 子痫前期 妊娠并发症 预防 

分 类 号：R714.23[医药卫生—妇产科学] R714.244[医药卫生—临床医学]