乳果糖与聚乙二醇电解质在结肠镜肠道准备中的应用比较:随机对照单盲临床研究  

Comparison of Lactulose and Polyethylene Glycol Electrolyte in Bowel Preparation Before Colonoscopy:A Randomized Controlled Single-blind Clinical Study

作　　者：年媛媛 孟宪梅[1] 栗鹏[1] 陈言东[1] 陈洪锁 曹佳馨 NIAN Yuanyuan;MENG Xianmei;LI Peng;CHEN Yandong;CHEN Hongsuo;CAO Jiaxin(Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region ,014030)

机构地区：[1]包头医学院第二附属医院消化内科,014030

出　　处：《胃肠病学》2020年第4期221-225,共5页Chinese Journal of Gastroenterology

基　　金：内蒙古自治区自然科学基金(2018MS08050,2019LH08042);内蒙古自治区科技计划项目(201803020)。

摘　　要：背景:充分的肠道准备是提高结肠镜检查有效性和阳性率的重要环节,目前临床中应用的缓泻药物均存在一定缺点和局限性,探索理想的肠道准备药物具有重要的临床价值。目的:比较乳果糖、聚乙二醇电解质在结肠镜肠道准备中的效果。方法:选取2019年6月—2019年11月于包头医学院第二附属医院拟行结肠镜检查的患者150例,并随机分为乳果糖组和聚乙二醇电解质组,泻药分两阶段服用。收集患者基本信息、肠道准备中主观感受和不良反应、排便次数和末次粪便性状等资料,对各段肠道的清洁度和泡沫程度进行评分。结果:乳果糖组和聚乙二醇电解质组患者的性别、年龄、BMI、文化程度、平时粪便性状、每日排便次数相比差异均无统计学意义。乳果糖组患者Stage 1排便次数、排便总次数显著高于聚乙二醇电解质组(P<0.05),降结肠清洁度评分显著低于聚乙二醇电解质组(P<0.05)。乳果糖组对泻药的口感评分显著低于聚乙二醇电解质组(P<0.05),但口干发生率显著升高(P<0.05)。相关性分析显示降结肠、乙状结肠清洁度与Stage 1排便次数呈负相关(P<0.05),直肠清洁度与排便总次数呈负相关(P<0.05)。结论:乳果糖在结肠镜肠道准备中具有良好的应用价值,其口感优于聚乙二醇电解质。评估Stage 1排便次数或总排便次数可优化肠道准备质量、提高各段肠道的清洁度。Background:Bowel preparation is important for improving the effectiveness and positivity rate of colonoscopy.At present,all laxative drugs used in clinical medicine have certain shortcomings and limitations.Exploring ideal bowel preparation drug has important clinical value.Aims:To compare the effectiveness of lactulose and polyethylene glycol electrolyte in bowel preparation before colonoscopy.Methods:A total of 150 patients underwent colonoscopy from June 2019 to November 2019 at the Second Affiliated Hospital of Baotou Medical College were enrolled and randomly divided into the lactulose group and the polyethylene glycol electrolyte group,and the laxatives were taken in two stages.The patient’s basic information,subjective feelings and adverse reactions during bowel preparation,the stool frequency and the last stool consistency were collected.The score of cleanliness and foam of each segments of intestine were estimated.Results:No significant differences in gender,age,BMI,education level,stool consistency and frequency were found between lactulose group and polyethylene glycol electrolyte group.Stool frequency in Stage 1 and the total stool frequency in lactulose group were significantly higher than those in polyethylene glycol electrolyte group(P<0.05),however,cleanliness score of descending colon was significantly lower(P<0.05).The taste score was significantly lower in lactulose group than in polyethylene glycol electrolyte group(P<0.05),and the incidence of thirst was significantly higher in lactulose group(P<0.05).Correlation analysis showed that cleanliness of descending colon,sigmoid colon were negatively correlated with stool frequency in Stage 1(P<0.05),cleanliness of rectum was negatively correlated with total stool frequency(P<0.05).Conclusions:Lactulose has good application value in bowel preparation before colonoscopy,and its taste is better than polyethylene glycol electrolyte.Evaluating the stool frequency in Stage 1 and total stool frequency can optimize the quality of bowel preparation and e

关 键 词：乳果糖 聚乙二醇电解质 肠道准备 结肠镜检查 

分 类 号：R47[医药卫生—护理学]