医用组织粘合剂的研究进展  

Medical Tissue Adhesives:Research Progress

作　　者：朱浩方 毛宏理 顾忠伟[1,2] ZHU Haofang;MAO Hongli;GU Zhongwei(College of Materials Science and Engineering,Nanjing Tech University,Nanjing 211816,China;Research Institute for Biomaterials,Tech Institute for Advanced Materials,Nanjing Tech University,Nanjing 211816,China)

机构地区：[1]南京工业大学材料科学与工程学院,江苏南京211816 [2]南京工业大学新材料研究院生物材料研究所,江苏南京211816

出　　处：《中国材料进展》2020年第7期535-550,共16页Materials China

基　　金：国家自然科学基金项目(31771067,31800803);江苏省重点研发计划项目(BE2018010-3);国家重点研发计划项目(2017YFC1103501);南工人才启动经费项目(39803130,39803129)。

摘　　要：医用组织粘合剂因其具有操作简便、无创粘合、即时密封和止血作用、可有效缩短手术时间等显著优势,获得了医疗领域的广泛关注,并逐渐成为传统手术缝合线的有效辅助或替代手段。目前,已有多种基于各类材料的商业化医用组织粘合剂被批准用于心脏、血管、肺等软组织的修复再生。然而,现有的大多数市售医用组织粘合剂仍然面临着粘合强度不够、功能单一、原料昂贵、生物相容性欠佳、安全隐患等挑战,临床上对于开发新型高效的多功能软组织粘合剂的需求极为迫切。在简要介绍各类软组织粘合剂的研究现状和粘合机制的基础上,对当前医用软组织粘合剂的研究热点、面临挑战及其临床转化应用情况进行了阐述,最后提出了未来的研究重点和发展趋势。Medical tissue adhesives have gained wide attention because of their obvious advantages over conventional sutures such as easy operation,non-invasive sealing,and immediate hemostasis.At present,a variety of commercial medical tissue adhesives based on various materials have been developed to replace or assist sutures in the application of repair and regeneration of heart,blood vessels,lungs and other soft tissues.However,existing tissue adhesives are usually either cytotoxic,fragile,or lacking adhesive strength.Therefore,significant research endeavors have been focused on developing a safe and effective tissue adhesive to overcome these problems.In this review,we firstly introduce the basic research status and adhesion mechanism of various types of tissue adhesives.Then the current hotspots and recent progress of medical tissue adhesives,as well as their clinical translation applications are summarized in detail.Finally,the future research direction and the prospect of tissue adhesives are proposed.

关 键 词：医用软组织粘合剂 商业化医用粘合剂 研究进展 临床转化 

分 类 号：R318.08[医药卫生—生物医学工程]