重庆某社区中国人内脏脂肪指数与2型糖尿病发病的相关性分析  

Correlation between the incidence of type 2 diabetes mellitus to Chinese visceral adiposity index in a community population of Chongqing City

作　　者：张书平 张晓静 汪志红[3] 曾朝阳[1] Zhang Shu-Ping;Zhang Xiao-Jing;Wang Zhi-Hong;Zeng Zhao-Yang(Department of Endocrinology,Yichang Central People's Hospital,Yichang,Hubei 443000,China;Department of Cardiovascular Medicine,Yichang Central People's Hospital,Yichang,Hubei 443000,China;Department of Endocrinology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400013,China)

机构地区：[1]宜昌市中心人民医院内分泌科,湖北宜昌443000 [2]宜昌市中心人民医院心血管内科,湖北宜昌443000 [3]重庆医科大学附属第一医院内分泌科,重庆400013

出　　处：《解放军医学杂志》2020年第7期725-729,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家临床重点专科建设项目(ZHTNB-2013-1231-0550)。

摘　　要：目的研究中国人内脏脂肪指数(CVAI)与2型糖尿病(T2DM)发病风险的相关性。方法以2013年重庆主城某社区参加健康体检的成人为研究对象,共收集原始体检资料6426人份(其中男性3568人,女性2858人),排除部分不符合要求的数据后,最终共纳入5039例(男性2834例,女性2205例)研究对象进行横断面研究。将研究对象分为男性、女性组;根据CVAI值的四分位数将研究对象分为男性、女性Q1、Q2、Q3、Q4组;比较各组一般资料及血糖、血脂、尿酸等生化指标水平,采用二元logistic回归分析不同CVAI值纳入者的T2DM发病风险。结果对年龄、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白、血尿酸等可能影响糖尿病发病的混杂因素进行校正后,男性CVAI值的Q2、Q3、Q4组相对于Q1组,发生T2DM的风险分别为1.146倍(OR=1.146,95%CI:0.764~1.718)、2.033倍(OR=2.033,95%CI:1.378~3.000)和3.247倍(OR=3.247,95%CI:2.175~4.849);女性CVAI值的Q2、Q3、Q4组相对于Q1组,发生T2DM的风险分别为1.583倍(OR=1.583,95%CI:0.634~3.954)、3.108倍(OR=3.108,95%CI:1.222~7.905)和3.814倍(OR=3.814,95%CI:1.350~10.773)。结论CVAI为T2DM发病的独立危险因素,随着CVAI值的增加,T2DM发病风险增高。Objective To investigate the correlation between the Chinese visceral adiposity index(CVAI)and the morbidity risk of type 2 diabetes mellitus(T2DM).Methods A total of 6426 subjects(3568 males,2858 females)from a community of Chongqing City who participated in a medical examination in 2013 were recruited.After exclusion of faulty data or missing information,the final samples for analysis included 5039 subjects(2834 males,2205 females).Subjects were firstly divided into male group and female group,and then,according to CVAI index quartiles,the both groups were respectively divided into 1st(Q1),2nd(Q2),3rd(Q3)and 4th(Q4)quantile group.Anthropometric data(including blood glucose,lipid levels,uric acid)were compared among each group.The risk of T2DM in subjects with different CVAI index was analyzed with logistic regression analysis.Results After adjusting possible confounding factors affecting diabetes,such as age,systolic pressure,diastolic pressure,levels of total cholesterol,triglyceride,low-density lipoprotein and uric acid,compared with the risks of T2DM in 1st(Q1)CVAI quartiles,that in 2nd(Q2),3rd(Q3)and 4th(Q4)CVAI quartiles for males were 1.146(OR=1.146,95%CI:0.764-1.718),2.033(OR=2.033,95%CI:1.378-3.000)and 3.247(OR=3.247,95%CI:2.175-4.849),and that in 2nd(Q2),3rd(Q3)and 4th(Q4)CVAI quartiles for females were 1.583(OR=1.583,95%CI:0.634-3.954),3.108(OR=3.108,95%CI:1.222-7.905)and 3.814(OR=3.814,95%CI:1.350-10.733).Conclusion Higher CVAI is the independent risk factor for the T2DM in Chinese adults.

关 键 词：中国人内脏脂肪指数 2型糖尿病 腹型肥胖 危险因素 

分 类 号：R587.1[医药卫生—内分泌]