致耐受性细胞对自身免疫性甲状腺炎的治疗作用研究进展  

Advances in research on the effects of tolerance cells on the treatment of autoimmune thyroiditis

作　　者：任子愚 陶玥廷 冉涛 周敏[1] 刘东方[1] Ren Zi-Yu;Tao Yue-Ting;Ran Tao;Zhou Min;Liu Dong-Fang(Department of Endocrinology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院内分泌代谢科,重庆400010

出　　处：《解放军医学杂志》2020年第7期781-785,共5页Medical Journal of Chinese People's Liberation Army

摘　　要：耐受性是指人体对药物或其他因素导致的机体内环境状态改变反应性降低的一种状态。耐受性是一种生物学现象,是药物或化学因子作用的自然结果。自身免疫性甲状腺炎(AIT)是机体对甲状腺腺体免疫耐受性发生改变,在一系列“多余”的抗原抗体结合反应中,由于特异或非特异性炎症而导致甲状腺组织破坏。近几年,针对自身免疫性疾病,全球范围内相继开发出了多种以提升机体耐受性为目的的体细胞治疗方式。该文主要论述致耐受性细胞用于AIT这类特殊自身免疫性疾病的治疗前景,并对相关研究进行总结探讨。Tolerance is a state in which the human body is less responsive to changes in internal environmental status caused by drugs or other factors.Tolerance is a biological phenomenon,a natural consequence of the action of drugs or chemical factors.Altered organismal tolerance status often leads to the development of multiple autoimmune diseases.Autoimmune thyroiditis(AIT)is a particular type of autoimmune disease,and is exactly the result of an altered immune tolerance of the thyroid gland to a series of"redundant"antigen-antibody binding reactions that produce specific or non-specific inflammation leading to tissue destruction of the thyroid gland.In recent years,a variety of somatic cell therapies have been developed for the purpose of improving the body's tolerance,partially used in the clinical treatment of autoimmune diseases such as systemic lupus erythematosus,multiple sclerosis and Crohn's disease,etc.Such somatic cells that can regulate tolerance are called tolerogenic cells.The present paper will focus mainly on the specific autoimmune diseases such as AIT,discuss the promising therapeutic implications of tolerogenic cells for this group of diseases,and provide a summary of relevant studies.Hopefully,it will provide new research directions for the treatment of the disease.

关 键 词：致耐受性细胞 间充质干细胞 自身免疫性甲状腺炎 调节性T细胞 耐受性树突细胞 

分 类 号：R593.2[医药卫生—内科学]