多囊卵巢综合征患者性激素、血脂、体重指数与抗缪勒氏管激素异常的相关性分析  

Correlation analysis of sex hormone,blood lipid and body mass index with anti-mullerian hormone abnormality in patients with polycystic ovarian syndrome

作　　者：王静 WANG Jing(Department of Laboratory Medicine,Maternal and Child Health Care Hospital of Ganzhou City,Jiangxi Province,Ganzhou 341000,China)

机构地区：[1]江西省赣州市妇幼保健院检验科,江西赣州341000

出　　处：《中国当代医药》2020年第25期190-193,共4页China Modern Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2019ZSF 242)。

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者性激素、血脂、体重指数(BMI)与抗缪勒氏管激素(AMH)异常的相关性。方法选取2018年1月~2019年12月我院收治的50例PCOS患者作为研究对象,纳入观察组。同期选取我院的50例健康体检者纳入对照组。测定两组研究对象血清样本中的AMH、性激素[促黄体生成素(LH)、卵泡生成素(FSH)、垂体泌乳素(PRL)、雌二醇(E2)、睾酮(TESTO)、孕酮(PROG)]、血脂[总胆固醇(CHOL)、三酰甘油(TG)]含量以及BMI,并进行PCOS患者性激素、血脂、BMI与AMH的相关性分析。结果观察组的BMI、LH、E2、TESTO、CHOL、TG、AMH均高于对照组,PRL、FSH、PROG低于对照组,差异有统计学意义(P<0.05)。Pearson分析结果显示,PCOS患者的BMI、LH、E2、TESTO、CHOL、TG水平与AMH成正相关(r>0,P<0.05);PRL、FSH、PROG与AMH成负相关(r<0,P<0.05)。结论PCOS患者血清中的AMH与性激素(LH、FSH、PRL、E2、TESTO、PROG)、血脂(CHOL、TG)和BMI均存在一定的相关性,故采用上述指标对PCOS患者进行早期筛查、治疗和预防都具有一定的临床意义。Objective To investigate the correlation of sex hormone,blood lipid and body mass index(BMI)with anti-mullerian hormone(AMH)abnormality in patients with polycystic ovarian syndrome(PCOS).Methods A total of 50 patients with PCOS who admitted to the hospital from January 2018 to December 2019 as the research objects were included in observation group,and 50 healthy controls during the same period in our hospital were included in control group.The AMH,sex hormones(luteinizing hormone[LH],follicle stimulating hormone[FSH],prolactin[PRL],estradiol[E2],testosterone[TESTO],progesterone[PROG]),blood lipid(total cholesterol[CHOL],triglyceride[TG])contents and BMI of all PCOS patients and healthy controls were measured in serum samples from both groups,and the correlation of sex hormone,blood lipid,BMI and AMH in PCOS patients were analyzed.Results The BMI,LH,E2,TESTO,CHOL,TG and AMH in observation group were higher than those in control group,and the PRL,FSH,PROG in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).Pearson analysis showed that the levels of BMI,LH,E2,TESTO,CHOL and TG in PCOS patients were positively correlated with AMH(r>0,P<0.05).The PRL,FSH and PROG were negatively correlated with AMH(r<0,P<0.05).Conclusion The serum AMH has certain correlation with sex hormone(LH,FSH,PRL,E2,TESTO,PROG),blood lipid(CHOL,TG)and BMI in patients with PCOS.Therefore,early screening,treatment and prevention for PCOS patients have certain clinical significance.

关 键 词：多囊卵巢综合征 性激素 血脂 体重指数 抗缪勒氏管激素 相关性 

分 类 号：R711.75[医药卫生—妇产科学]