基于Th17/Treg细胞失衡探讨小柴胡汤治疗慢性乙肝的机制  

Discussion on the Mechanism of Xiaochaihu Decoction in the Treatment of Chronic Hepatitis b Based on Th17/Treg Cell Imbalance

作　　者：宋银芳 赫伟丽[2] 韩安晖 SONG Yinfang;HE Weili;HAN Anhui(Department of Infectious Diseases,Beijing Chinese Medicine Hospital Shunyi Hospital,Beijing 101300,China;Department of Infectious Diseases,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;The 984 Hospital of the Chinese People′s Liberation Army Integrated Chinese and Western Medicine,Beijing 100094,China)

机构地区：[1]北京中医医院顺义医院感染性疾病科,北京101300 [2]北京中医药大学东直门医院感染科,北京100700 [3]中国人民解放军第九八四医院中西医结合科,北京100094

出　　处：《世界中医药》2020年第17期2593-2597,共5页World Chinese Medicine

基　　金：北京中医药科技发展资金青年研究项目(QN2014-013)。

摘　　要：目的:探讨小柴胡汤对慢性乙型肝炎疗效及对Th17/Treg细胞的影响。方法:选取2017年7月至2019年2月北京中医医院顺义医院收治的慢性乙肝患者150例作为研究对象,按照入院编号分为对照组和观察组,每组75例。对照组常规西药治疗,观察组加用小柴胡汤治疗。观察入组时、疗程完成时肝功能、T淋巴细胞亚群、肝纤维化、慢性肝病特异性量表(CLDQ)、Th17/Treg细胞变化并比较。结果:完成治疗后2组患者ALT、TBIL、GLB、ALB、PTA、TNF-α、CD3^+、CD4^+、CD4^+/CD8^+、CD8^+、Treg、IL-10、TGF-β1、Th17、IL-17、IL-23、HA、PCⅢ、Ⅳ-C、LN及临床症状体征积分均较治疗前有明显改善,且观察组患者改善幅度均优于对照组患者(P<0.05)。结论:小柴胡汤能提高慢性乙肝患者肝功能和免疫功能,改善肝纤维化,提高生存治疗,促使Th17/Treg细胞趋向平衡。Objective:To explore the effects of Xiaochaihu Decoction on chronic hepatitis B and Th17/Treg cells.Methods:A total of 150 patients with chronic hepatitis B admitted to Beijing Chinese Medicine Hospital Shunyi Hospital were divided into a control group and an observation group,with 75 cases in each group.The control group was treated with Western medicine,and the study group was treated with Xiaochaihu Decoction.The changes of liver function,T lymphocyte subsets,liver death,CLDQ and Th17/Treg cells were observed and compared.Results:After the treatment,ALT,TBIL,GLB,ALB,PTA,TNF-α,CD3^+,CD4^+,CD4^+/CD8^+,CD8^+,Treg,IL-10,TGF-β1,Th17,IL-17,IL-23,ha,PCⅢ,Ⅳ-C,LN and clinical symptoms and signs of the patients in the observation group were significantly improved compared with those before treatment(P<0.05).Conclusion:Xiaochaihu Decoction can improve the liver function and immune function of chronic hepatitis B patients,improve liver fibrosis,improve survival treatment,and promote the balance of Th17/Treg cells.

关 键 词：小柴胡汤 慢性乙型肝炎 TH17/TREG细胞 疗效 肝功能 肝纤维化 慢性肝病特异性量表 T淋巴细胞亚群 

分 类 号：R256.43[医药卫生—中医内科学] R512.62[医药卫生—中医学]