不同黏膜给药途径与载体优化的研究进展  

Research Progress of Different Mucosal Administration Routes and Carrier Optimization

作　　者：解嘉慧 宋薇 孙祎昕 肖宇[1] XIE Jiahui;SONG Wei;SUN Yixin;XIAO Yu(State Key Laboratory of Oral Diseases,West China School of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学口腔疾病研究国家重点实验室,四川大学华西口腔医学院,成都610041

出　　处：《中国现代应用药学》2020年第12期1517-1521,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金青年项目(81701027);中国博士后科学基金面上项目(2017M623049)。

摘　　要：黏膜给药因具有便捷无创、直接进入体循环及给药部位多等优点而成为传统侵入性给药方式的主要替代方法之一,为儿童、老年患者和对侵入性给药不耐受的患者提供了可接受的治疗方案。然而由于黏膜本身复杂而强大的生理屏障作用,药物的生物利用度仍处于较低水平。目前,新型药物递送系统多基于对载体的改性及对固有屏障的突破。本文就口腔黏膜、鼻黏膜、阴道黏膜、眼部黏膜、直肠黏膜和膀胱黏膜这6种主要黏膜给药途径的研究进展作一综述。Mucosal administration has become one of the main alternative methods of traditional invasive drug delivery because of its advantages such as convenient non-invasive,direct entry into the systemic circulation and multiple delivering sites.It also provides an acceptable treatment regimen for children,elderly,and the like who are intolerant to invasive administr ation.However,due to the complex and strong physiological barrier of the mucosa itself,the bioavailability of the drug is still at a low level.At present,new drug delivery systems are based on the modification of carriers and breakthroughs in inherent barriers.This article reviews the research progress of the six main mucosal routes of oral mucosa,nasal mucosa,vaginal mucosa,ocular mucosa,rectal mucosa and bladder mucosa.

关 键 词：黏膜给药 载体优化 生物材料 

分 类 号：R94[医药卫生—药剂学]