肾阻力指数联合NGAL在急性A型主动脉夹层术后急性肾损伤中的临床研究  

Clinical study on renal resistance index combined with NGAL in acute kidney injury after the surgery of acute type A aortic dissection

作　　者：匡智明 朱建龙 李君易 朱运林[1] 朱华勇[1] KUANG Zhiming;ZHU Jianlong;LI Junyi;ZHU Yunlin;ZHU Huayong(Department of Intensive Care Medicine,Ganzhou People's Hospital in Jiangxi Province,Ganzhou341000,China;Department of Intensive Care Medicine,Longnan County Hospital of TCM in Jiangxi Province,Longnan341700,China)

机构地区：[1]江西省赣州市人民医院重症医学科,江西赣州341000 [2]江西省龙南县中医院重症医学科,江西龙南341700

出　　处：《中国现代医生》2020年第22期13-15,19,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(20204563)。

摘　　要：目的分析肾阻力指数(RRI)+中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在急性A型主动脉夹层术后急性肾损伤(AKI)中的价值。方法回顾性研究本院2018年12月~2020年1月收治的72例急性A型主动脉夹层患者,根据术后是否合并AKI分组,将合并AKI的患者作为实验组,未合并AKI的患者作为对照组,检测并比较两组术后12 h、24 h、48 h、96 h的RRI、NGAL。比较RRI、NGAL单独检测与联合检测诊断急性A型主动脉夹层术后AKI的检出率。结果72例急性A型主动脉夹层患者,术后30例合并AKI,占41.67%;42例未合并AKI,占58.33%。实验组术后12 h、24 h、48 h、96 h的RRI、NGAL水平均明显高于对照组,RRI、NGAL联合检测诊断急性A型主动脉夹层术后AKI的检出率(96.67%)明显高于单独检测(76.67%、73.33%),差异有统计学意义(P<0.05)。结论RRI、NGAL与急性A型主动脉夹层合并AKI呈正相关,RRI+NGAL可显著提高急性A型主动脉夹层术后AKI诊断检出率,值得借鉴。Objective To analyze the value of renal resistance index(RRI)+neutrophil gelatinase-associated lipocalin(NGAL)in acute kidney injury(AKI)after the surgery of acute type A aortic dissection.Methods 72 patients with acute type A aortic dissection who were admitted to our hospital from December 2018 to January 2020 were retrospectively analyzed.The patients were grouped according to whether AKI was complicated after surgery.The patients with AKI were selected as the experimental group,and the patients without AKI were selected as the control group.The RRI and NGAL at 12 h,24 h,48 h and 96 h after surgery were detected and compared between the two groups.The detection rate of AKI was compared between single application and combined application of RRI and NGAL in the diagnosis of postoperative acute type A aortic dissection.Results Among 72 patients with acute type A aortic dissection,30 cases were complicated with AKI after surgery,accounting for 41.67%,and 42 cases were not complicated with AKI,accounting for 58.33%.The RRI and NGAL levels in the experimental group at 12 h,24 h,48 h,and 96 h were significantly higher than that in the control group after surgery.The detection rate of AKI after the combined application of RRI and NGAL in the diagnosis of postoperative acute type A aortic dissection(96.67%)was significantly higher than that of the detection alone(76.67%,73.33%),and all differences were statistically significant(P<0.05).Conclusion RRI and NGAL are positively correlated with acute type A aortic dissection complicated with AKI.RRI+NGAL can significantly improve the diagnostic detection rate of AKI after the surgery of acute type A aortic dissection,which is worthy of being learned.

关 键 词：肾阻力指数 中性粒细胞明胶酶相关脂质运载蛋白 急性A型主动脉夹层 急性肾损伤 

分 类 号：R543.1[医药卫生—心血管疾病]