类风湿关节炎患者血清炎症因子和氧化应激指标治疗前后水平的变化  

Level changes of serum inflammatory factors and oxidative stress indices before and after treatment in patients with rheumatoid arthritis

作　　者：丁仙红 朱红国 DING Xianhong;ZHU Hongguo(Department of Laboratory,Enze Hospital,Taizhou Enze Medical Center(Group)in ZhejiangProvince,Taizhou318050,China)

机构地区：[1]浙江省台州恩泽医疗中心(集团)恩泽医院检验科,浙江台州318050

出　　处：《中国现代医生》2020年第22期135-138,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020KY371)。

摘　　要：目的探讨类风湿关节炎(RA)患者血清炎症因子和氧化应激指标治疗前后水平的变化。方法选择2016年4月~2019年3月我院门诊就诊的RA患者50例(病例组),予以口服芬必得胶囊0.3 g/次,2次/d,连用2周。观察治疗前后血清炎症因子[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]和氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)]指标的变化。另选择同期的健康体检者30例作为健康组。结果病例组治疗前血清hs-CRP、IL-6和TNF-α水平较健康组更高(P<0.01);治疗2周后,病例组血清hs-CRP、IL-6和TNF-α水平均较前显著下降(P<0.05或P<0.01)。同时病例组治疗前血清MDA水平明显高于健康组,血清SOD和CAT水平明显低于健康组(P<0.01);治疗2周后,病例组血清MDA水平均较前明显下降,血清SOD和CAT水平较前明显上升(P<0.05或P<0.01)。结论RA患者体内存在炎症因子hs-CRP、IL-6、TNF-α水平紊乱和氧化应激指标MDA、SOD和CAT水平异常,血清hs-CRP、IL-6、TNF-α、MDA、SOD和CAT水平的变化可作为评估RA患者治疗疗效的敏感血清学指标。Objective To explore the level changes of serum inflammatory factors and oxidative stress indices before and after treatment in patients with rheumatoid arthritis(RA).Methods Fifty patients with RA treated in the outpatient department of our hospital from April 2016 to March 2019 were selected as the case group,and oral lbuprofen capsules 0.3 g/time,2 times/day were given for 2 weeks.The level changes of serum inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)]and oxidative stress indices[malondialdehyde(MDA),superoxide dismutase(SOD),and catalase(CAT)]before and after treatment were observed.Thirty people receiving healthy checkup in the same period were selected as the health group.Results The levels of serum hs-CRP,IL-6 and TNF-αbefore treatment were higher in the case group than in the health group(P<0.01);two weeks after treatment,the levels of serum hs-CRP,IL-6 and TNF-αin the case group were significantly declined(P<0.05 or P<0.01).The level of serum MDA before treatment was significantly higher in the case group than in the health group,and the levels of serum SOD and CAT before treatment were significantly lower in the case group than in the health group(P<0.01);two weeks after treatment,the level of serum MDA in the case group was significantly declined,and the levels of serum SOD and CAT in the case group were significantly elevated(P<0.05 or P<0.01).Conclusion There are level disorders of inflammatory factors(hs-CRP,IL-6,and TNF-α)and abnormal levels of oxidative stress indices(MDA,SOD,and CAT)in patients with RA.The level changes of serum hs-CRP,IL-6,TNF-α,MDA,SOD,and CAT can be used as sensitive serological indices to evaluate the therapeutic effect in patients with RA.

关 键 词：类风湿关节炎 超敏C反应蛋白(hs-CRP) 白介素-6(IL-6) 肿瘤坏死因子-α(TNF-α) 丙二醛(MDA) 超氧化物歧化酶(SOD) 过氧化氢酶(CAT) 

分 类 号：R593.2[医药卫生—内科学]