骨缺损修复中干细胞成骨分化调控因素研究进展  

Research progress of regulatory factors of osteogenic differentiation of stem cells in repairing bone defects

作　　者：李羚榕 刘玉梅 匙峰 陈真勇 LI Lingrong;LIU Yumei;SHI Feng;CHEN Zhenyong(West China Normal University,Collaborative Innovation Center for Organization and Repair Materials Engineering Technology,Nanchong637009,China;School of Life Science,West China Normal University,Nanchong637009,China;School of Environmental Science and Engineering,West China Normal University,Nanchong637009,China)

机构地区：[1]西华师范大学组织修复材料工程技术协同创新中心,四川南充637009 [2]西华师范大学生命科学学院,四川南充637009 [3]西华师范大学环境科学与工程学院,四川南充637009

出　　处：《中国现代医生》2020年第23期186-192,共7页China Modern Doctor

基　　金：西华师范大学博士科研启动基金(18Q069);四川省南充市研发资金项目(19YFZJ0097)。

摘　　要：干细胞因来源广泛、可自我更新、拥有多向分化潜能等优点,目前已广泛用于组织修复实验和临床研究,特别是在骨缺损修复中展现出良好的应用前景。在骨组织工程中,干细胞作为缺损修复支架的组成要素,为缺损修复提供细胞来源和活性基础,因此探究骨缺损修复中干细胞成骨分化的主要调控因素尤为重要。本文将从支架的材料组成、材料表面微观结构、空间宏观结构、外源性药物、体外刺激等因素综述骨组织工程中干细胞成骨分化调控因素、作用机理与研究进展,为骨缺损修复的基础研究与临床应用提供新思路。Stem cells have been widely used in tissue repair experiments and clinical research specially showing good application prospects in bone defect repair,due to their advantages of wide source,self-renewal,and multi-directional differentiation potential.In bone tissue engineering,stem cells,as a component of defect repair scaffolds,provide cell source and active basis for defect repair.Therefore,it is particularly important to explore the main regulatory factors of stem cell osteogenic differentiation in bone defect repair.In this article,we will review the regulatory factors,mechanism and research progress of osteogenic differentiation of stem cells in bone tissue engineering from the factors such as the material composition of the scaffold,the microstructure of the surface of the material,the macroscopic structure of the space,the exogenous drugs,and in vitro stimulation.This provides a new idea for the basic research and clinical applications of bone defect repair.

关 键 词：骨缺损修复 干细胞 成骨分化 支架 刺激 

分 类 号：R318[医药卫生—生物医学工程]