注射用血栓通对脑缺血损伤的药理研究现状  

Research status of pharmacology research on Xueshuantong injection for cerebral ischemia

作　　者：袁庆[1] 殷孟兰 赵磊 徐耀 柴丽娟[1] 王少峡[1] 郭虹[1] 胡利民[1] YUAN Qing;YIN Meng-lan;ZHAO Lei;XU Yao;CHAI Li-juan;WANG Shao-xia;GUO Hong;HU Li-min(Institute of Traditional Chinese Medicine(TCM),Tianjin University of TCM,Tianjin Key Laboratory of Chinese Medicine Pharmacology,Key Laboratory of Pharmacology of TCM Formulae,Ministy of Education,Tianjin 301600,China)

机构地区：[1]天津中医药大学中医药研究院、天津市中药药理学重点实验室、方剂学教育部重点实验室,天津301600

出　　处：《中国临床药理学杂志》2020年第16期2521-2524,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81573644);“十三五”期间天津市高等学校“创新团队培养计划”基金资助项目(TD13-5050)。

摘　　要：注射用血栓通具有活血化瘀、通脉活络的功效,临床上可用于治疗多种疾病,如缺血性脑血管疾病、冠心病、心绞痛、心肌梗塞等。其主要成分为三七总皂苷,主要包括人参皂苷Rg1、Rb1、Rd、Re及三七皂苷R1,现代药理研究表明,三七总皂苷具有改善脑循环,保护缺血再灌注后脑和神经损伤等作用。本文就注射用血栓通及其主要成分对脑缺血损伤的药理作用研究现状进行总结性综述,以期对血栓通临床前研究及临床用药提供一定的参考。Xueshuantong injection has the effect of activating blood circulation to remove blood stasis and promoting venous circulation. It can be used clinically to treat various diseases such as ischemic cerebrovascular disease,coronary heart disease,angina pectoris and myocardial infarction. Its main component is Panax notoginseng saponins,which mainly include ginsenoside Rg1, Rb1, Rd, Re and notoginsenoside R1. Modern pharmacological studies have shown that Panax notoginseng saponins can improve brain circulation and protect brain and nerve damage after ischemia-reperfusion. This article summarizes the research status of the pharmacological effects of Xueshuantong injection and its main components on cerebral ischemic injury, in order to provide a certain reference for preclinical research and clinical medication of Xueshuantong.

关 键 词：注射用血栓通 脑缺血 三七总皂苷 脑卒中 神经保护 

分 类 号：R28[医药卫生—中药学]