砷的胚胎发育毒性研究进展  

Effects of arsenic exposure on embryonic development

作　　者：李秀娟[1] 杨丽红[1] 赵陶然 奥瑞芳 刘志贞[1] 解军[1] LI Xiujuan;YANG Lihong;ZHAO Taoran;AO Ruifang;LIU Zhizhen;XIE Jun(Department of Biochemistry and Molecular Biology,Shanxi Key Laboratory of Birth Defect and Cell Regeneration,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学生物化学与分子生物学教研室,山西省出生缺陷与细胞再生重点实验室,太原030001

出　　处：《生命的化学》2020年第7期1041-1048,共8页Chemistry of Life

基　　金：山西省“1331工程”重点学科建设计划经费项目(1331KSC);山西省重点学科建设基金资助项目(FSKSC)。

摘　　要：胚胎发育除受自身基因调控外,还受外界环境因素的影响。砷普遍存在于自然界中,是一种严重威胁人类健康的环境污染物。研究表明砷除一般毒性和致癌效应外,还具有发育毒性。子宫内砷暴露会干扰胚胎的正常发育,导致流产、死产、出生缺陷、低出生体重等不良妊娠结局。本文从流行病学研究、动物体内及体外实验等方面综述了砷的胚胎发育毒性,并探讨其可能的作用机制,为砷污染地区预防出生缺陷、提高人口质量提供了依据。Embryonic development is not only regulated by the specific genes but also influenced by environmental factors.Arsenic is a metalloid widely existing in nature and poses a serious threat to human health.In addition to its general toxicity and carcinogenic effects,arsenic is also considered to be a developmental toxicant.Arsenic can cross the placenta in both animals and humans.It has been reported that arsenic exposure in utero may lead to spontaneous abortion,stillbirth,birth defects,decreased newborn birth weight or other adverse pregnancy outcomes.This paper is a review about the embryonic toxicity of arsenic from the aspects of epidemiology,animal studies and in vitro experiments.The possible mechanisms for how arsenic interferes with normal development of embryos were also concluded.

关 键 词：砷 胚胎发育 子宫内暴露 毒效应 

分 类 号：R114[医药卫生—卫生毒理学]