黑龙江省单中心785例儿童肾活检病理分析(2002年~2019年)  

Pathological analysis of renal biopsy of 785 children in single center of Heilongjiang Province from 2002 to 2019

作　　者：王羽晴 朱琳[1] 周萍[1] WANG Yuqing;ZHU Lin;ZHOU Ping(Pediatrics,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang)

机构地区：[1]哈尔滨医科大学附属第二医院儿科,哈尔滨150086

出　　处：《肾脏病与透析肾移植杂志》2020年第4期323-327,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：目的:从肾活检病理角度分析哈尔滨医科大学附属第二医院儿科近18年间儿童肾脏疾病肾组织病理学诊断的构成特征及其变化。方法:回顾性收集并分析2002年~2019年在我院行肾活检病理检查的肾脏疾病患儿资料,并将研究对象按时间先后分为第一阶段(2002年~2010年)和第二阶段(2011年~2019年)进行横断面对比分析。结果:(1)一般情况:研究共纳入肾活检患儿785例,男女比例为1.43∶1,0~6岁、7~12岁和13~18岁患儿所占肾活检患儿比例分别为68例(8.66%)、262例(33.38%)、455例(57.96%)。(2)病理类型:原发性肾小球疾病占76.94%,继发性肾小球疾病占21.14%,遗传性及先天性肾脏疾病占0.76%,肾小管间质疾病占1.15%。(3)病理谱变迁:轻微病变性肾小球肾炎是第一阶段最常见原发性肾小球疾病,IgA肾病是第二阶段最常见原发性肾小球疾病。狼疮性肾炎和紫癜性肾炎的构成比分别从第一阶段的0.86%和4.31%显著增加到第二阶段的7.59%和18.44%。结论:原发性肾小球疾病仍是影响我国儿童健康的主要肾脏疾病,近年来IgA肾病明显增加,是本组患儿最常见原发性肾小球疾病。紫癜性肾炎和狼疮性肾炎是最常见的继发性肾小球疾病。Objective:To analyze characteristics and changes of renal histopathological diagnosis of children’s renal diseases in the Second Affiliated Hospital of Harbin Medical University. Methodology:Data of children with renal diseases who underwent renal biopsy in our hospital from 2002 to 2019 were collected and analyzed retrospectively. The subjects were divided into the first stage(2002-2010) and the second stage(2011-2019) for cross-sectional comparative analysis. Results:(1) General situation:785 children with renal biopsy were included in the study,ratio of male and female was 1.43∶ 1,ratio of children aged 0-6,7-12 and 13-18 years accounted for 8.66%(68 cases),33.38%(262 cases) and 57.96%(455 cases),respectively.(2) Pathological types:primary glomerular diseases accounted for 76.94%,secondary glomerular diseases accounted for 21.14%,hereditary and congenital kidney diseases accounted for 0.76%,renal tubulointerstitial diseases accounted for 1.15%.(3) Pathological spectrum change:mild pathological glomerulonephritis is the most common primary glomerulonephritis in the first stage,IgA nephropathy is the most common primary glomerulonephritis in the second stage.The proportion of lupus nephritis(LN) and Henoch-Schonlein purpura nephritis(HSPN) increased from 0.86% and 4.31% in the first stage,and increased to 7.59% and 18.44% in the second stage,respectively. Conclusion:Primary glomerular disease is still the main renal disease of children in this center. IgA nephropathy has become the most common primary glomerular disease in recent years,HSPN and LN are the main pathological types of secondary glomerular diseases.

关 键 词：肾脏病理 流行病学 肾活检 疾病谱 

分 类 号：R726.9[医药卫生—儿科]