非蛋白尿型糖尿病肾病  

Non⁃proteinuria diabetic nephropathy

作　　者：马妍(综述) 谢红浪(审校) MA Yan;XIE Honglang(National Clinical Research Center of Kidney Diseases,Jinling hospital,Nanjing University School of Medicine,Nanjing 210016,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院) [2]国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2020年第4期369-374,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：糖尿病肾病是糖尿病最常见的严重并发症,也是慢性肾脏病进展到终末期肾脏病的主要病因之一。糖尿病肾病早期表现为肾小球内高压力、高灌注和高滤过,随后出现微量白蛋白尿、显性蛋白尿、肾小球滤过率降低,最终可发展为终末期肾病。近年来,糖尿病患者蛋白尿的发生率有所下降,但肾小球滤过率减低的发生率上升,提示非蛋白尿型糖尿病肾病的发病率升高,引起多种血管并发症和肾功能降退。因此,了解非蛋白尿型糖尿病肾病的发病机制,诊断标志物和治疗措施,是有效治疗糖尿病肾病改善疾病预后的基础。As the major complication of diabetes,diabetic nephropathy is also the major cause of progression from chronic kidney disease to end stage renal disease.However,the incidence of non⁃proteinuria diabetic nephropathy(NP⁃DN)in patients with type 2 diabetes is gradually increasing,causing vascular complications and renal function decrease.Therefore,understanding the pathogenesis,diagnostic markers and therapies of NP⁃DN is the basis of effective treatment of diabetic nephropathy.

关 键 词：糖尿病肾病 非蛋白尿型糖尿病肾病 肾血管并发症 

分 类 号：R58[医药卫生—内分泌]