儿童外阴阴道炎病原学与耐药性分析  

Etiology and drug resistance analysis of vulvovaginitis in children

作　　者：潘宇琛[1] 柳静[1] 刘慧丽[1] 张淼[1] PAN Yuchen;LIU Jing;LIU Huili;ZHANG Miao(Department of Traditional Chinese Medicine,Beijing Children′s Hospital,Capital Medical University/National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心/首都医科大学附属北京儿童医院中医科,北京100045

出　　处：《国际检验医学杂志》2020年第18期2198-2202,共5页International Journal of Laboratory Medicine

基　　金：国家重点研发计划(2017YFC1703205)。

摘　　要：目的分析儿童外阴阴道炎的病原学与耐药性情况,为临床防治工作提供参考依据。方法选取2018年1—12月该院门诊首次就诊的外阴阴道炎患儿4089例为研究对象,分析其中661例病原菌培养阳性标本的菌株分布情况、药敏试验结果,比较单纯中药治疗与中西医联合治疗的复发率。结果夏季和冬季是儿童外阴阴道炎高发季节;感染率最高的4种病原菌由高到低依次为流感嗜血杆菌(38.21%)、化脓性链球菌(30.01%)、金黄色葡萄球菌(7.91%)和肺炎链球菌(4.83%);单纯中药治疗与中西医结合治疗停药后复发率分别为14.89%和11.87%,差异无统计学意义(P>0.05)。结论积极完善病原菌培养,并根据药敏试验结果合理使用抗菌药物对儿童外阴阴道炎的治疗具有重要意义;中药治疗与中西医结合治疗儿童外阴阴道炎的疗效均较好。Objective To analyze the etiology and drug resistance of vulvovaginitis in children,and provide reference for clinical prevention and treatment.Methods A total of 4089 children with vulvovaginitis who received their first visit to the hospital from January to December 2018 were selected as the research objects,the bacterial strain distribution and drug sensitivity test results of 661 positive samples of pathogen culture were analyzed,and the recurrence rate of traditional Chinese medicine treatment and combined Chinese and Western medicine treatment were compared.Results Summer and winter were the seasons for children with high incidence of vulvovaginitis.The 4 kinds of pathogens with the highest infection rate were Haemophilus influenzae(38.21%),Streptococcus pyogenes(30.01%),Staphylococcus aureus(7.91%)and Streptococcus pneumoniae(4.83%)in descending order.The recurrence rates after treated with Chinese medicine alone and combined Chinese and Western medicine treatment were 14.89%and 11.87%respectively,and the difference was not statistically significant(P>0.05).Conclusion It is of great significance to improve the pathogen culture and rationally use antimicrobial agents according to the results of drug sensitivity test for the treatment of vulvovaginitis in children.The curative effect of traditional Chinese medicine and combined traditional Chinese and Western medicine in children with vulvovaginitis are better.

关 键 词：外阴阴道炎 儿童 病原学 药敏试验 

分 类 号：R711.31[医药卫生—妇产科学]