骨桥蛋白在侵入性胎盘和正常胎盘组织中的表达差异研究  

Differences in expression of osteopontin in invasive placenta and normal placental tissue

作　　者：黄琳玲[1] 吴娟[1] Huang Linling;Wu Juan(Department of Gynaecology,Jiangxi Maternal and Child Health Hospital,Nanchang,Jiangxi,330006,China)

机构地区：[1]江西省妇幼保健院妇科,江西南昌330006

出　　处：《当代医学》2020年第29期63-65,共3页Contemporary Medicine

摘　　要：目的探究侵入性胎盘和正常胎盘组织中骨桥蛋白(OPN)的表达差异。方法选取2019年10月至2020年4月江西省妇幼保健院产科收治的81例单胎分娩孕妇为研究对象。根据胎盘组织是否侵入或粘连分为3组,将正常胎盘组织作为对照组(n=41),将侵入性胎盘组织作为研究组(n=40),结合胎盘侵入类型再分为胎盘粘连组(n=21)与胎盘植入组(n=19)。观察比较3组胎盘组织OPN蛋白阳性表达率以及PCR检测结果。结果胎盘粘连组、胎盘植入组OPN蛋白表达阳性率分别为76.19%(16/21)、73.68%(14/19),显著高于对照组的34.15%(14/41),差异有统计学意义(P<0.05);胎盘粘连组OPN mRNA较对照组上调1.37倍,胎盘植入组OPN mRNA上调1.23倍。结论骨桥蛋白表达的升高是侵入性胎盘突出的临床特征,其在侵入性胎盘诊断及预后评估中具有较高的临床价值。Objective To investigate the expression differences of osteopontin(OPN)in invasive placenta and normal placental tissue.Methods 81 pregnant women with single-child delivery admitted to the department of obstetrics of Jiangxi provincial maternal and child health care hospital from October 2019 to April 2020 were selected as the study subjects.According to the invasion or adhesion of placental tissue,normal placental tissue was used as the control group(n=41),and invasive placental tissue was used as the research group(n=40).Combined with the type of placental invasion,it was further divided into the placental adhesion group(n=21)and the placental implantation group(n=19).The positive expression rate of OPN protein and PCR detection results among 3 groups of placental tissues were observed and compared.Results The positive expression rates of OPN protein in the placental adhesion group and the placental implantation group were 76.19%(16/21)and 73.68%(14/19),respectively,which were significantly higher than those in the control group(34.15%,14/41),and the difference was statistically significant(P<0.05).Compared with the control group,OPN mRNA of the placental adhesion group was increased by 1.37 times,and that of the placental implantation group was increased by 1.23 times.Conclusion The increased expression of osteopontin is a prominent clinical feature of invasive placenta,and it has a high clinical value in the diagnosis and prognosis assessment of invasive placenta.

关 键 词：骨桥蛋白 侵入性胎盘 阳性表达 胎盘粘连 胎盘植入 

分 类 号：R714.462[医药卫生—妇产科学]