冠心病患者PCI手术前后FGF-21、VEGF及GTGF的变化与心功能的关系  

Changes of Fibroblast Growth Factor-21,Vascular Endothelial Growth Factor and GTGF in Patients with Coronary Heart Disease before and after PCI and Their Relationship with Cardiac Function

作　　者：郭华[1] GUO Hua(The Second People’s Hospital of Zhengzhou City,He’nan Province 450000)

机构地区：[1]河南省郑州市第二人民医院,450000

出　　处：《医学理论与实践》2020年第18期2961-2963,2960,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨冠心病(CHD)患者经皮冠脉介入术(PCI)前后患者血清成纤维细胞生长因子21(FGF-21)、血管内皮细胞生长因子(VEGF)、结缔组织生长因子(GTGF)的变化与心功能变化的关系。方法:选取我院2017年9月—2018年10月实施PCI手术治疗的CHD患者77例(CHD组)、健康体检人群77例(对照组),采用ELISA检测两组的血清FGF-21、VEGF、GTGF水平,采用超声心动图检测CHD组患者术前、术后6个月的左室射血分数(LVEF%)、左室舒张末期内经(LVEDd)、左室短轴缩短率(LVFS),并进行相关性分析。结果:CHD组患者在PCI术前、术后1周的血清FGF-21、VEGF及GTGF水平均显著的高于对照组(P<0.05);CHD组患者在PCI术后1周,血清FGF-21、GTGF水平较术前显著的降低(P<0.05),VEGF水平较术前显著升高(P<0.05);CHD组患者在PCI术前、术后1周的LVEF%、LVFS%水平均显著的低于对照组(P<0.05),LVEDd测定值高于对照组(P<0.05);CHD组患者在PCI术后6个月,LVEF%、LVFS%水平较术前显著的升高(P<0.05),LVEDd较术前显著的降低(P<0.05);CHD组患者在PCI术前血清FGF-21、GTGF水平与LVEF%、LVFS%水平均呈显著的负相关关系(P<0.05),血清FGF-21、GTGF水平与LVEDd测定值呈显著的正相关关系(P<0.05)。结论:CHD患者PCI术前及术后的血清FGF-21、GTGF水平较健康人群显著升高,VEGF在PCI术后升高,PCI术前血清FGF-21、GTGF水平升高与患者术后心功能恢复有关。Objective:To investigate the relationship between the changes of serum fibroblast growth factor 21(FGF-21),vascular endothelial growth factor(VEGF),connective tissue growth factor(GTGF)and cardiac function in patients with coronary heart disease(CHD)before and after percutaneous coronary intervention(PCI).Methods:77 CHD patients who underwent PCI(CHD group)and 77 healthy people(control group)from September 2017 to October 2018 were selected.Serum levels of FGF-21,VEGF and GTGF were measured by ELISA.Left ventricular ejection fraction(LVEF%),left ventricular end diastolic diameter(LVEDd)and left ventricular short axis shortening rate(LVFS)were measured by echocardiography before and 6 months after operation in CHD group,and perform correlation analysis.Results:Serum FGF-21,VEGF and GTGF levels were significantly higher in the CHD group than in the control group before and 1 week after surgery(P<0.05).In the CHD group,1 week after PCI,the level of serum FGF-21 and GTGF was significantly lower than that before surgery(P<0.05),and the level of VEGF was significantly higher than that before surgery(P<0.05).The LVEF%and LVFS%levels of patients in the CHD group were significantly lower than those in the control group before and 1 week after surgery(P<0.05),and the LVEDd values were higher than those in the control group(P<0.05).At 6 months after operation,LVEF%and LVFS%levels were significantly higher than those before surgery(P<0.05),and LVEDd was significantly lower than before surgery(P<0.05).In patients with CHD before surgery,there was a significant negative correlation between GTGF level,serum FGF-21 and LVEF%,LVFS%levels(P<0.05).There was a significant positive correlation between serum FGF-21 and GTGF levels,LVEDd(P<0.05).Conclusion:The levels of serum FGF-21 and GTGF in CHD patients before and after PCI were significantly higher than those in healthy people.The levels of VEGF increased after PCI.The elevated levels of serum FGF-21 and GTGF before PCI were related to the recovery of cardiac function.

关 键 词：冠心病 经皮冠脉介入术 成纤维细胞生长因子21 血管内皮细胞生长因子 结缔组织生长因子 

分 类 号：R541.4[医药卫生—心血管疾病]