绝经前女性CHD患者激素水平与其血浆CTRP3、免疫球蛋白水平及冠状动脉斑块稳定性的关系  

The relationship between hormone levels and plasma CTRP3,immunoglobulin levels and coronary plaque stability in premenopausal women with CHD

作　　者：王世杰[1] 李珊 王晓纲[1] 李璞[1] 魏庆民[1] WANG Shi-jie;LI Shan;WANG Xiao-gang;LI Pu;WEI Qing-min(Department of Cardiology, People′s Hospital of Xingtai City, Hebei Province, Xingtai 054000, China)

机构地区：[1]河北省邢台市人民医院心血管内科,河北邢台054000

出　　处：《河北医科大学学报》2020年第9期1016-1019,1038,共5页Journal of Hebei Medical University

摘　　要：目的研究绝经前女性冠心病(coronary atherosclerotic heart disease,CHD)患者雌激素水平与其血浆C1q/肿瘤坏死因子相关蛋白3(C1q/tumor necrosis factor-relatedprotein3,CTRP3)、免疫球蛋白水平及冠状动脉斑块稳定性的关系。方法选取绝经前女性冠心病患者50例作为研究对象,以同期治疗的绝经前25例健康女性作为对照组。分析绝经前女性CHD患者雌激素水平与其血浆CTRP3、免疫球蛋白水平及冠状动脉斑块稳定性的关系。结果观察组CTRP3、IgA、IgM、IgG、血清雌二醇(estradiol,E2)、卵泡生成激素(follicle-stimulating hormone,FSH)、黄体生成激素(luteinising hormone,LH)水平显著低于对照组,患者的CTRP3、IgA、IgM、IgG、E2、FSH、LH水平从高到低依次为对照组、稳定型心绞痛组以及急性冠状动脉综合征组,冠状动脉中层厚度、斑块面积以及斑块数量均显著高于对照组,从两两比较的结果分析,斑块稳定性从高到低依次为对照组、稳定型心绞痛组以及急性冠状动脉综合征组(P<0.05)。患者的E2、FSH、LH水平分别与冠状动脉中层厚度、斑块面积、斑块数量、CTRP3、IgA、IgM、IgG水平呈现正相关(P<0.05)。结论绝经前女性CHD患者激素水平与其血浆CTRP3、免疫球蛋白水平及冠状动脉斑块稳定性存在一定的关联性,建议在临床诊疗中将雌激素水平作为绝经前女性CHD患者患病危险程度的评价指标之一。Objective To study the relationship between hormone levels and plasma CTRP3,immunoglobulin levels and coronary plaque stability in premenopausal women with coronary atherosclerotic heart disease(CHD).Methods The subjects of this study were 50 premenopausal women with coronary heart disease,and 25 healthy premenopausal women treated in our hospital during the same period as the control group.The relationship between hormone levels and plasma CTRP3,immunoglobulin levels and coronary plaque stability in premenopausal women with CHD were analyzed.Results The levels of CTRP3,IgA,IgM,IgG,E2,FSH and LH in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).The levels of CTRP3,IgA,IgM,IgG,E2,FSH and LH in the observation group were in turn as the control group,stable angina group and acute coronary syndrome group,with the middle thickness of the artery,plaque surface(P<0.05).The area and number of plaques were significantly higher than those in the control group(P<0.05).From the analysis of the results of two comparisons,the order of plaque stability from high to low was the control group,stable angina pectoris group and acute coronary syndrome group(P<0.05).The levels of E2,FSH and LH were positively correlated with the thickness of middle arterial layer,plaque area,plaque number,CTRP3,IgA,IgM and IgG levels,respectively(P<0.05).Conclusion Hormone levels in premenopausal women with CHD are correlated with plasma CTRP3,immunoglobulin levels and coronary plaque stability.It is suggested that sex hormone levels should be used as one of the indicators of the severity of CHD in clinical diagnosis and treatment.

关 键 词：冠心病 性腺甾类激素 绝经前期 

分 类 号：R541.4[医药卫生—心血管疾病]