多指标正交试验优选菟杞强肾口服液超滤工艺研究  

Optimization of Ultrafiltration Technology for TuQi QiangShen Oral Liquid by Multi-targets Orthogonal Test

作　　者：陶松[1] 刘玲[2] 魏筱华[1] 潘德城[1] 周健[1] 段舟萍[1] TAO Song;LIU Ling;WE Xiao-hua;PAN De-cheng;ZHOU Jian;DUAN Zhou-ping(Department of Pharmacy,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Pharmacy,Jiangxi provincial People′s Hospital,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院药学部,江西南昌330006 [2]江西省人民医院药学部,江西南昌330006

出　　处：《海峡药学》2020年第8期4-8,共5页Strait Pharmaceutical Journal

基　　金：江西省卫生计生委中医药科研基金(编号:2016A074)。

摘　　要：目的优选菟杞强肾口服液超滤工艺。方法以总多糖转移率、总黄酮转移率、淫羊藿苷转移率、干膏得率为考察赘标,以超滤功率、超滤压力、药液生药浓度为考察因素,采用正交试验优选菟杞强肾口服雍的超滤工艺。结果优选超滤工艺采用超滤功率为80%、超滤压力为4.5bar、药液生药浓度在25~35mg·mL^(-1)。结论优选出的超滤工艺有效成分转移率高、药液质量稳定、便于操作。OBJECTIVE To optimize the ultrafiltration technology of Tuqi qiangshen oral liquid.METHODS Ultrafiltration technology of TuQi QiangShen Oral liquid was oqtimized by orthogonal test with total polysaccharide transfer rate,total flavonoid transfer rate,icariin transfer rate and drypaste yield rate as indexes,using ultrafiltration power,ultrafiltration pressure and concentration of crude medicine as factors.RESULTS The optimal technology was as follows:ultrafiltration power 80%,ultrafiltration pressure 4.5 bar,concentration of crude medicine 25-35mg·mL-1.CONCLUSION Optimal technology is stable in quality and easy to operation with high transfer rate.

关 键 词：菟杞强肾口服液 正交试验 超滤工艺 多指标 

分 类 号：R94[医药卫生—药剂学]