阿利沙坦酯联合蕲蛇酶治疗高血压性肾病(Ⅱ期)的临床研究  

Clinical study of Arsartan medoxomil combined with snake snake enzyme in the treatment of hypertensive nephropathy(PhaseⅡ)

作　　者：刘星宇 段崇毅 刘英华 Liu Xingyu;Duan Chongyi;Liu Yinghua(The Chinese medicine hospital of Jiujiang city,Jiangxi 332000)

机构地区：[1]九江市中医医院,江西九江332000

出　　处：《基层医学论坛》2020年第28期4001-4003,共3页The Medical Forum

基　　金：江西省卫生健康委科技计划(20204304)。

摘　　要：目的探讨阿利沙坦酯联合蕲蛇酶治疗高血压性肾病(Ⅱ期)的临床效果。方法选取2018年5月—2019年5月期间收治的50例高血压性肾病患者,随机分为观察组和对照组各25例,对照组采用阿利沙坦酯片加以常规治疗,观察组在对照组基础上增加蕲蛇酶注射液。比较2组血红蛋白(Hb)、白蛋白(Alb)和24 h尿蛋白的差异,以及肾功能[血肌酐(SCr)、尿素氮(BUN)、血清胱抑素C]水平。结果2组治疗前后Hb、Alb比较,均无显著性差异(P>0.05);治疗后观察组24 h尿蛋白低于对照组,差异具有显著性(P<0.05)。观察组治疗后SCr为(90.25±21.54)umol/L、BUN为(9.21±1.88)mmol/L、血清胱抑素C为(1.02±0.32)mg/L,低于对照组的(154.24±17.35)umol/L、(11.36±2.39)mmol/L和(1.76±0.41)mg/L,差异有统计学意义(P<0.05)。结论阿利沙坦酯联合蕲蛇酶治疗高血压性肾病(Ⅱ期)患者能有效改善肾功能水平,减少蛋白尿排出、提高肌酐清除率,值得推广。Objective To explore the clinical effect of alipartan medoxomil and enzymase on hypertensive nephropathy(PhaseⅡ).Methods 50 patients with hypertensive nephropathy from May 2018 to May 2019 were randomly divided into observation There were 25 cases in each group and control group.The control group was treated with alishartan medoxomil tablets,and the observation group added cyprinus enzyme injection on the basis of the control group.The difference between hemoglobin(Hb),albumin(Alb)and 24-hour urinary protein,as well as renal function[blood creatinine(SCr),urea nitrogen(BUN),serum cystatin C levels were compared between the two groups.Results There was no significant difference in Hb and Alb between the two groups before and after treatment(P>0.05),and the difference in urine protein at 24 hours was significant(P<0.05).The Scr of the observation group after treatment was(90.25±21.54)umol/L,the BUN level was(9.21±1.88)mmol/L and the serum cystatin C(1.02±0.32)mg/L was lower than that of the control group(154.24±17.35)Umol/L,BUN(11.36±2.39)mmol/L and serum cystatin C(1.76±0.41)mg/L,the difference was statistically significant(P<0.05).Conclusion In the treatment of hypertensive nephropathy(PhaseⅡ)patients with arsartan medoxomil and enzymase,you can improve the renal function,reduce proteinuria excretion,increase the creatinine clearance,and improve the blood coagulation function of the patients.It is worth popularizing and applying.

关 键 词：高血压性肾病(Ⅱ期) 阿利沙坦酯片 蕲蛇酶 临床疗效 

分 类 号：R692[医药卫生—泌尿科学] R544.1[医药卫生—外科学]