Protective Effect of Shenlingbaizhu Powder on Peroxidation Injury and Inflammatory Response in Mice with Pneumonia  

作　　者：Jinli FENG Cheng ZHANG Houjun CHEN Ziliang CHEN Yongfeng CHEN Zhiguang WU 

机构地区：[1]Zhongshan Chinese Medicine Hospital , Zhongshan 528400, China

出　　处：《Medicinal Plant》2020年第4期75-77,共3页药用植物：英文版

摘　　要：[Objectives]The study aims to explore the protective effect of Shenlingbaizhu powder on peroxidation injury and inflammatory response in mice with pneumonia.[Methods]60 NIH mice were randomly divided into the blank group,model group,control group,large dose group,medium dose group and small dose group of Shenlingbaizhu powder.The mice in the control group were given cefixime granules,while the mice in each group of Shenlingbaizhu powder were given corresponding concentrations of Shenlingbaizhu powder water decoction by gavage.After 7 d,the content of MAD,SOD and CRP in the mice were detected by ELISA,while the content of NO was detected by fluorescence,and lung index was also detected.[Results]The medium dose and large dose of Shenlingbaizhu powder can effectively reduce the concentration of MAD and improve the level of SOD in mice with pneumonia.The effect of the large dose of Shenlingbaizhu powder is more obvious than that of the control group.Moreover,the large dose of Shenlingbaizhu powder can effectively reduce the level of NO in mice with pneumonia.In addition,the medium dose and large dose of Shenlingbaizhu powder can reduce the lung index and CRP level of mice with pneumonia,and the results are statistically significant.[Conclusions]The medium dose and large dose of Shenlingbaizhu powder can effectively reduce the concentration of MAD and improve the level of SOD in mice with pneumonia.The effect of the large dose of Shenlingbaizhu powder is more obvious than that of the control group.Moreover,the large dose of Shenlingbaizhu powder can effectively reduce the level of NO in mice with pneumonia.In addition,the medium dose and large dose of Shenlingbaizhu powder can reduce the lung index and CRP level of mice with pneumonia,and the results are statistically significant.

关 键 词：Shenlingbaizhu powder PNEUMONIA MAD SOD NO CRP Lung index 

分 类 号：R28[医药卫生—中药学]