Development of mouse preimplantation embryos in space  

作　　者：Xiaohua Lei Yujing Cao Baohua Ma Yunfang Zhang Lina Ning Jingjing Qian Liwen Zhang Yongcun Qu Tao Zhang Dehong Li Qi Chen Junchao Shi Xudong Zhang Chiyuan Ma Ying Zhang Enkui Duan 

机构地区：[1]State Key Laboratory of Stem Cell and Reproductive Blology,Institute of Zoology,Chnese Academy of Scences,Beijing 100101,China [2]College of Veterinary Medicine,Northwest A&FUniversity/Key Laboratory of Anamal Biotechnology,Ministry of Agriculture,Yanglng 712100,China [3]University of Chinese Academy of Sciences,Beijng 100049,China [4]Shanghai Institute of Technical Physics,Chinese Academy of Sciences,Shanghai 100049,China [5]Divsion of lonzng Radiaton,National Institute of Metrology,Beijing 100029,China

出　　处：《National Science Review》2020年第9期1437-1446,共10页国家科学评论（英文版）

基　　金：This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA04020202-20 to E-K.D.);the Ministry of Science and Technology of China(2018YFC1004500 to Y.Z.);the National Natural Science Foundation of China(U 1738103 to E-K.D.,31600683 to X-H.L.and 31671201 to Y.Z.);the Strategically Guiding Scientific Special Project from the Chinese Academy of Sciences(XDA15014000 to X-H.L.);the National Key Research and Development Program of China(2017YFC1001401 and 81490742 to E-K.D.).

摘　　要：The development o f life beyond planet Earth is a long-standing quest of the human race,but whether normal mammalian embryonic development can occur in space is still unclear.Here,we show unequivocally that preimplantation mouse embryos can develop in space;but the rate of blastocyst formation and blastocyst quality are compromised.Additionally,the cells in the embryo contain severe DNA damage,while the genome of the blastocysts developed in space is globally hypomethylated with a unique set of differentially methylated regions.The developmental defects,DNA damage and epigenetic abnormalities can be largely mimicked by the treatment with ground-based low-dose radiation.However,the exposure to simulated microgravity alone does not cause major disruptions of embryonic development,indicating that radiation is the main cause for the developmental defects.This work advances the understanding of embryonic development in space and reveals long-term extreme low-dose radiation as a hazardous factor for mammalian reproduction.

关 键 词：SPACE-FLIGHT RADIATION MICROGRAVITY preimplantation development DNA damage DNA methylation 

分 类 号：S814.8[农业科学—畜牧学]