缺血性亚急性期卒中后抑郁患者默认网络静息态功能磁共振研究  

Resting-state functional magnetic resonance study of default mood network in patients with subacute post-ischemic stroke

作　　者：张佩瑶[1] 王晶[2] 王君[3] 戴建平[4] ZHANG Peiyao;WANG Jing;WANG Jun;DAI Jianping(Department of Radiology,China-Japan Friendship Hospital,Beijing 100029,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;State Key Laboratory of Cognitive Neuroscience and Learning&IDG/Mc Govern Institute for Brain Research,Beijing Normal University,Beijing 100875,China;Department of Neuroimaging,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]中日友好医院放射科,北京100029 [2]首都医科大学附属北京天坛医院神经内科,北京100050 [3]北京师范大学认知神经科学与学习国家重点实验室,北京100875 [4]首都医科大学附属北京天坛医院神经影像中心,北京100050

出　　处：《磁共振成像》2020年第8期615-619,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的研究亚急性期缺血性卒中后抑郁(post-stroke depression,PSD)患者默认网络功能连接的变化与卒中后抑郁发生的相关性。材料与方法对26例卒中后抑郁患者、24例卒中后无抑郁患者及24名正常被试行静息态功能磁共振扫描,计算并比较其默认网络功能连接的变化,之后计算功能连接的变化与汉密尔顿抑郁评分(Hamilton Depression Rate Scale,HDRS)的相关性。结果卒中后抑郁患者与正常对照组和卒中后无抑郁患者相比,其默认网络功能连接存在变化,且左侧顶下回与双侧后扣带回之间的功能连接与HDRS评分呈正相关。结论默认网络的变化可能与卒中后抑郁的发生有关。Objective:This study identified altered functional connectivity(FC)in patients with post-stroke depression(PSD)at the subacute phase in default mood network(DMN).The correlation between FC and the severity of PSD was also investigated.Materials and Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)was performed on 26 PSD patients,24 stroke patients without depression,and 24 age-matched normal controls.The FC values of DMN were calculated and compared among the three groups.The Hamilton Depression Rating Scale(HDRS)(17 items)was employed and the score was correlated with FC in the PSD group.Results:The FCs of DMN were altered in PSD patients at the subacute phase compared to stroke patients without depression and normal controls(NC).Moreover,the left inferior parietal gyrus(which indicated altered FC)were significantly correlated with HDRS scores in PSD patients.Conclusions:Alteration of DMN might be correlated with the development of PSD at the subacute phase of stroke.

关 键 词：卒中后抑郁 默认网络 功能磁共振成像 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]