pH敏感CEST MRI对比剂研究进展  

CEST MR contrast agent for pH-sensitive imaging

作　　者：阿荣 乔文菊 孙晓红 周江伟 孙夕林[1,2] A Rong;QIAO Wenju;SUN Xiaohong;ZHOU Jiangwei;SUN Xilin(TOF-PET/CT/MR Center,The Fourth Hospital of Harbin Medical University,Harbin 150028,China;Molecular Imaging Research Center,Harbin Medical University(MIRC),Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOFPET/CT/MR中心,哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,哈尔滨150028

出　　处：《磁共振成像》2020年第8期712-716,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81627901);国家重点基础研究发展计划(编号:2015CB931800)。

摘　　要：化学交换饱和转移(chemical exchange saturation transfer,CEST)MRI是一种磁化转移技术,它是基于化学交换理论基础上发展起来的磁共振成像新方法。CEST作为MR新兴成像方法的重要分支,在分子成像及各种代谢功能测定方面具有研究和应用潜力,尤其是在肿瘤酸性微环境研究中,其具备能够定性定量检测细胞外pH值的独特优势。实体肿瘤的酸性微环境是导致肿瘤的增殖、转移、侵袭等恶性病理生理学行为以及放化疗抵抗的重要因素。因此,在体、无创、实时、动态并且精准地监测肿瘤细胞外pH(pHe)值能为肿瘤微环境相关的机制研究,为肿瘤诊断及治疗疗效监测提供全新的技术方法和分子功能水平评估手段。在CEST MR成像中,外源性引入的MR对比剂是成功实现pH值精准定量的必须前提、关键内容和技术核心。本综述从基础研究及临床应用需求出发,对目前已研发的pH敏感CEST MR对比剂展开述评,讨论现有对比剂在本领域开展应用情况以及各自优缺点,以期为新型pH敏感CEST MR对比剂的设计、制备、研发及应用提供理论依据和数据支撑。Chemical exchange saturation transfer(CEST)is a magnetic resonance imaging(MRI)methods developed on the basis of magnetization transfer technology and Chemical exchange theory.As an emerging method of MR imaging,CEST MRI has a broad application prospects in molecular imaging and various metabolic studies.Also,extracellular acid pH level of solid tumors is known to be associated with tumor proliferation,metastasis,invasion,radiotherapy and chemotherapy resistance.Therefore,accurate,non-invasive,and dynamic detection of extracellular pH(pHe)value of solid tumors could provide biological information for the detection of tumor acidosis and the efficacy of early anticancer treatment.This review mainly summarizes the application of several pH-sensitive CEST contrast agents alongside their advantages and otherwise.

关 键 词：化学交换饱和转移 肿瘤酸性微环境 对比剂 PH值 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R318[医药卫生—诊断学]