人腺病毒工程化应用研究进展  

Progress in engineering application of human adenovirus

作　　者：赵阳 张其威[2] 夏雪山[1] Yang Zhao;Qiwei Zhang;Xueshan Xia(Yunnan Provincial Center for Molecular Diagnosis,Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,Yunnan,China;College of Public Health,Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南省分子诊断工程技术研究中心,云南昆明650500 [2]南方医科大学公共卫生学院,广东广州510515

出　　处：《生物工程学报》2020年第7期1269-1276,共8页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.U1702282)资助。

摘　　要：人腺病毒流行广泛,感染常诱发呼吸道疾病、流行性结膜炎等疾病。腺病毒是研究较为深入的一类病原体,并且作为病毒载体已广泛应用,也是基因治疗最常用的病毒载体,尤其在肿瘤基因治疗和病毒溶瘤方面具有较大的研究价值和临床应用潜力。文中对腺病毒的生物学特性以及应用范围等方面进行综述,以期为腺病毒的工程化与临床应用提供参考。Human adenoviruses are widespread causative agent that induces respiratory diseases,epidemic keratoconjunctivitis and other related diseases.Adenoviruses are commonly used in experimental and clinical areas.It is one of the most commonly used virus vectors in gene therapy,and it has attracted a lot of attention and has a high research potential in tumor gene therapy and virus oncolytic.Here,we summarize the biological characteristics,epidemiology and current application of adenovirus,in order to provide reference for engineering application of adenovirus.

关 键 词：人腺病毒 载体 溶瘤 工程化应用 

分 类 号：R373[医药卫生—病原生物学]