炎性因子在2型糖尿病冠脉循环障碍中作用的研究进展  

Research Progress on the Role of Inflammatory Factors in Coronary Artery Circulatory Disorder with Type 2 Diabetes Mellitus

作　　者：付红梅(综述) 胡军(审校)[1] FU Hong-mei;HU Jun(Liyuan Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院,武汉430000

出　　处：《微循环学杂志》2020年第3期69-76,共8页Chinese Journal of Microcirculation

摘　　要：糖尿病(DM)是一种内分泌代谢障碍性疾病,其中以2型糖尿病(T2DM)最为常见,主要发病机制是胰岛素抵抗(IR)伴胰岛素分泌不足,疾病后期多种并发症并存,尤其心血管并发症是DM患者致残、致死的主要原因。现越来越多的证据表明T2DM是炎性因子介导的血管内皮炎症反应,炎性因子可通过IR、胰岛β细胞损伤或干扰信号传导等多途径参与T2DM的发生、发展。本文回顾了各炎性因子对T2DM的作用,将目前研究较多的炎性因子如:C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、核转录因子(NF-κB)、白介素-8(IL-8)、白介素-12(IL-12)、白介素-18(IL-18)以及白介素-10(IL-10)在T2DM冠脉循环、微循环中的作用作一综述,提出既然是炎性因子介导的炎症发应,就应针对相应炎性因子及其信号传导途径等发生机制给予对应抗炎治疗及阻碍信号传导,延缓或阻止T2DM心血管并发症发生,改善T2DM冠脉循环、微循环,降低T2DM心血管死亡率,提高T2DM患者预后。Diabetes mellitus(DM)is a kind of endocrine metabolic disorder.Type 2 diabetes(T2DM)is the most common,the main pathogenesis is insulin resistance(IR)with insufficient insulin secretion,and multiple complications coexist in the later stage of the disease,especially cardiovascular complications are the main cause of disability and death in DM patients.More and more evidence shows that T2DM is a vascular endothelial inflammatory response mediated by inflammatory factors,which can be involved in the occurrence and development of T2DM through multiple pathways,such as IR,islet cell damage or interference with signal transduction.This article reviews the various inflammatory factors in T2DM,at present,the most common inflammatory factors such as C-reactive protein(CRP),tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6),a nuclear transcription factor(NF-kappa B),interleukin 8(IL-8),interleukin 12(IL-12),interleukin-18(IL-18),interleukin 10(IL-10).The roles of these inflammatory factors in T2DM with coronary circulation and microcirculation are reviewed.It is suggested that since inflammation mediated by inflammatory factors occurs,the corresponding anti-inflammatory treatment and the blocking of signal transduction should be given according to the corresponding inflammatory factors and signal transduction pathways,delay or prevent T2DM cardiovascular complications,improve T2DM coronary circulation,microcirculation,reduce cardiovascular mortality in T2DM,and improve the prognosis of T2DM patients.

关 键 词：2型糖尿病 冠脉循环 冠脉微循环 炎性因子 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]