自发性早产患者IL-6、TNF-α、PAF水平变化及危险因素分析  

Changes of IL-6, TNF-α and PAF Levels and Risk Factors in Patients with Spontaneous Preterm Birth

作　　者：刘会雪 尹红亚[1] 童重新[1] 何瑞芝[1] 高芳 LIU Hui-xue;YIN Hong-ya;TONG Chong-xin;HE Rui-zhi;GAO Fang(Department of Obstetrics and Gynecology,Children's Hospital of Hebei Province,Shijiazhuang 050031,China)

机构地区：[1]河北省儿童医院妇产科,石家庄050031

出　　处：《解放军医药杂志》2020年第9期85-88,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省医学科学研究重点课题计划项目(20190784)。

摘　　要：目的分析自发性早产患者的白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血小板激活因子(PAF)水平变化及其危险因素。方法选择2018年10月—2019年10月收治的单胎自发性早产179例作为早产组,同时选择正常产检的未发生自发性早产者96例作为对照组。回顾性分析2组一般临床资料,并测定IL-6、TNF-α及PAF水平。应用Logistic多因素回归分析对自发性早产的危险因素进行分析。结果早产组的IL-6水平高于对照组(P<0.01)。2组的TNF-α、PAF水平比较差异无统计学意义(P>0.05)。年龄、妊娠期糖尿病、妊娠期高血压、前置胎盘、胎盘早剥、胎膜早破、IL-6水平是自发性早产的危险因素(P<0.05,P<0.01)。结论自发性早产病因复杂,应对孕期妇女进行综合性评估,对有危险因素存在的孕妇采取有效干预,以避免不良妊娠结局,提高母婴生存质量。Objective To explore the changes in the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),platelet activating factor(PAF)and their risk factors of spontaneous preterm birth(SPTB)in patients.Methods A total of 179 cases with singleton pregnancy and SPTB from October 2018 to October 2019 were selected as the preterm group,and 96 cases without SPTB who underwent prenatal examination were selected as the control group.General clinical data of the two groups were analyzed retrospectively,and IL-6,TNF-αand PAF levels were measured.The risk factors of SPTB were analyzed by Logistic multivariate regression analysis.Results The level of IL-6 in the preterm group was higher than that in the control group(P<0.01).There was no significant difference in the levels of TNF-αand PAF between the two groups(P>0.05).Age,gestational diabetes mellitus,gestational hypertension,placenta previa,placental abruption,premature rupture of membranes and IL-6 levels are risk factors for SPTB(P<0.05,P<0.01).Conclusion The etiology of SPTB is complicated,therefore,a comprehensive evaluation of pregnant women should be performed,and effective interventions should be taken on pregnant women with risk factors,to avoid adverse pregnancy outcomes and improve the quality of life of mothers and infants.

关 键 词：自发性早产 妊娠并发症 白介素-6 血小板激活因子 肿瘤坏死因子-Α 危险因素 回归分析 

分 类 号：R714.21[医药卫生—妇产科学]