职业性铅接触工人氧化应激及免疫功能状况调查  

Investigation on oxidative stress and immune function of occupationally lead-exposed workers

作　　者：顾呈华[1] 张恒东[1] 朱宝立[1] 窦建瑞 金武 杨晶晶 魏静 王适之[3] 赵义[4] 张翠翠 GU Chenghua;ZHANG Hengdong;ZHU Baoli;DOU Jianrui;JIN Wu;YANG Jingjing;Wei Jing;WANG Shizhi;ZHAO Yi;ZHANG Cuicui(Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,Jiangsu210009,China;Yangzhou Center for Disease Control and Prevention,Yangzhou,Jiangsu 225001,China;School of Public Health,Southeast University,Nanjing,Jiangsu 210009,China;Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu 225001,China;Jiangsu Ousha Environmental Testing Technology Co.,Ltd.,Nanjing,Jiangsu 211500,China)

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009 [2]扬州市疾病预防控制中心,江苏扬州225001 [3]东南大学公共卫生学院,江苏南京210009 [4]扬州大学附属医院,江苏扬州225001 [5]江苏省欧萨环境检测技术有限公司,江苏南京211500

出　　处：《职业卫生与应急救援》2020年第4期338-341,共4页Occupational Health and Emergency Rescue

基　　金：江苏省自然科学基金(BK20181488);江苏省临床医学科技专项(BL2014082);江苏省预防医学会课题项目(Y2018056);扬州市“十三五”科教强卫重点专项(ZDRC201829)。

摘　　要：目的探索体内不同浓度的铅负荷对男性工人氧化应激及免疫功能造成的影响。方法以某蓄电池厂工人为研究对象,探讨了血铅与氧化应激及免疫功能的关系。结果共纳入130名蓄电池厂男性作业人员作为研究对象,其中高铅组(血铅>300μg/L)34人,中铅组(200μg/L≤血铅≤300μg/L)51人,低铅组(血铅值<200μg/L)45人。与低铅组比较,中铅组人群的SOD水平升高(P<0.05),其余各组之间的MDA、SOD、GSH-Px水平差异均无统计学意义(P>0.05)。高铅组人群TNF-α水平高于低铅组、中铅组(P<0.05);其余各组之间的IgG、IgA、IgM、C3、C4、IL-2水平差异均无统计学意义(P>0.05)。3组人群中从低铅组到高铅组,ZPP的水平逐渐升高(P<0.05)。血铅浓度和外周血TNF-α(rs=0.213,P<0.05)、ZPP(rs=0.513,P<0.01)呈正相关,其余指标与血铅浓度之间无相关性(P>0.05)。结论随着血铅浓度的升高,铅可能对机体有一定的氧化损伤和免疫损伤倾向。Objective To study the adverse effects of lead exposure on oxidative stress and immune function of male workers.Methods The workers in a battery factory were studied and the relationship between their blood lead and oxidative stress and immune function was evaluated.Results A total of 130 male workers in this battery factory were included and according to blood lead levels they were divided into 3 groups,namely high lead exposure group(blood lead>300μg/L,34 workers),medium lead exposure group(200μg/L≤blood lead≤300μg/L,51 workers)and low lead exposure group(blood lead value<200μg/L,45 workers).Workers in medium lead exposure group had a higher level of SOD(P<0.05),while there were no significant difference of MDA,SOD,and GSH-Px levels among these workers(P>0.05).TNF-αlevel of workers in the high lead exposure group was higher(P<0.05),while there were no significant differences of IgG,IgA,IgM,C3,C4,and IL-2 levels among these workers(P>0.05).ZPP level of workers gradually increased with the increment of blood lead and the differences were statistically significant(P<0.05)among workers in 3 groups.Blood lead concentrations were significantly correlated with peripheral blood TNF-α(rs=0.213,P<0.05)and ZPP(rs=0.513,P<0.01),while the correlations between the other indicators and blood lead concentrations were not statistically significant(P>0.05).Conclusion Higher blood lead concentration may have a certain adverse effect on oxidative stress and immune function among occupationally lead-exposed workers.

关 键 词：铅 氧化损伤 免疫毒性 血锌原卟啉 超氧化物歧化酶 肿瘤坏死因子Α 

分 类 号：R135.1[医药卫生—劳动卫生]