银杏叶片联合阿替洛尔治疗急性心肌梗死的临床研究  

Clinical study on Yinxingye Tablets combined with atenolol in treatment of acute myocardial infarction

作　　者：于培[1] 李斌[2] YU Pei;LI Bin(Department of Pharmacy,Branch of Tianjin Third Central Hospital,Tianjin 300250,China;Department of Cardiology,Branch of Tianjin Third Central Hospital,Tianjin 300250,China)

机构地区：[1]天津市第三中心医院分院药剂科,天津300250 [2]天津市第三中心医院分院心内科,天津300250

出　　处：《现代药物与临床》2020年第8期1638-1641,共4页Drugs & Clinic

摘　　要：目的研究银杏叶片联合阿替洛尔片治疗急性心肌梗死的临床疗效。方法选取2018年1月—2019年6月在天津市第三中心医院分院治疗的120例急性心肌梗死患者,将所有患者随机分为对照组和治疗组,每组各60例。对照组口服阿替洛尔片,6.25~12.5 mg/次,2次/d。治疗组在对照组基础上口服银杏叶片,2片/次,3次/d。两组患者持续治疗14 d。观察两组患者临床疗效,对比两组的心功能指标和血清生化指标水平。结果治疗后,对照组和治疗组的总有效率分别为81.67%、95.00%,差异有统计学意义(P<0.05)。治疗后,两组患者左心室舒张末期内径(LVEDD)显著降低,左心室射血分数(LVEF)和左心室高峰充盈率(LVPFR)显著升高(P<0.05),且治疗组心功能指标改善较明显(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)、N-末端脑钠肽前体(NT-proBNP)、肌酸激酶(CK)和内皮素-1(ET-1)水平均显著降低(P<0.05);并且治疗组血清生化指标水平降低较明显(P<0.05)。结论银杏叶片联合阿替洛尔片治疗急性心肌梗死具有较好的治疗效果,能够改善心肌功能,降低血清生化指标水平。Objective To study the clinical effect of Yinxingye Tablets combined with Atenolol Tablets in treatment of acute myocardial infarction.Methods Patients(120 cases)with acute myocardial infarction in Branch of Tianjin Third Central Hospital from January 2018 to June 2019 were randomly divided into control and treatment groups,and each group had 60 cases.Patients in the control group were po administered with Atenolol Tablets,6.25—12.5 mg/time,twice daily.Patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group,2 tablets/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacies were evaluated,and cardiac function index and biochemical indexes levels in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 81.67%and 95.00%,respectively,and there was difference between two groups(P<0.05).After treatment,the LVEDD in two groups was significantly decreased,but the LVEF and LVPFR in two groups were significantly increased(P<0.05).And the cardiac function indexes in the treatment group were significantly improved than those in the control group(P<0.05).After treatment,the serum levels of IL-6,NT proBNP,CK,and ET-1 in the two groups were significantly decreased(P<0.05),and the biochemical indexes in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Yinxingye Tablets combined with Atenolol Tablets has clinical curative effect in treatment of acute myocardial infarction,can improve myocardial function,and reduce the serum level of biochemical indexes.

关 键 词：银杏叶片 阿替洛尔片 急性心肌梗死 心功能指标 生化指标 

分 类 号：R972[医药卫生—药品]