醋氯芬酸缓释片治疗膝骨关节炎的疗效观察  

Clinical observation of Aceclofenac Sustained-release Tablets in treatment of knee osteoarthritis

作　　者：庄俊雪 潘霖[2] ZHUANG Jun-xue;PAN Lin(Tianjin Baodi Hospital,Baodi Clinical College of Tianjin Medical University,Tianjin 301800,China;Tianjin First Center Hospital,Tianjin 300192,China)

机构地区：[1]天津市宝坻区人民医院天津医科大学宝坻临床学院,天津301800 [2]天津市第一中心医院,天津300192

出　　处：《现代药物与临床》2020年第8期1680-1683,共4页Drugs & Clinic

摘　　要：目的探讨醋氯芬酸缓释片治疗膝骨关节炎的临床疗效。方法选取2018年1月—2019年12月在天津市第一中心医院治疗的96例膝骨关节炎患者作为研究对象,按照不同治疗方法将所有患者分为常规片组、缓释片组,每组各48例。常规片组口服醋氯芬酸片,100 mg/次,2次/d。缓释片组口服醋氯芬酸缓释片,200 mg/次,1次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组治疗前后视觉模拟评分法(VAS)评分、关节功能评分、日常生活能力评分。结果治疗后,缓释片组患者的总有效率(97.9%)明显高于常规片组(87.5%),两组数据组间差异具有统计学意义(P<0.05)。治疗后,两组患者VAS评分、关节功能评分、日常生活能力评分均显著降低(P<0.05),且缓释片组患者VAS评分、关节功能、日常生活能力评分明显低于常规片组(P<0.05)。结论醋氯芬酸缓释片治疗骨关节炎具有较好的临床疗效,能够缓解患者疼痛,改善患者关节功能、日常生活能力。Objective To explore the clinical effects of Aceclofenac Sustained-release Tablets in treatment of knee osteoarthritis.Methods Patients(96 cases)with knee osteoarthritis in Tianjin First Center Hospital from January 2018 to December 2019 were randomly divided into conventional tablets and sustained-release tablets groups,and each group had 48 cases.Patients in the conventional tablets group were po administered with Aceclofenac Tablets,100 mg/time,twice daily.Patients in the sustained-release tablets group were po administered with Aceclofenac Sustained-release Tablets on the basis of the conventional tablets group,200 mg/time,once daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and VAS scores,joint function scores,and activity of daily living scores in two groups were compared.Results After treatment,the total effective rate of the sustained-release tablets group(97.9%)was significantly higher than that of the conventional tablets group(87.5%),and there was difference between two groups(P<0.05).After treatment,VAS scores,joint function scores,and activity of daily living scores of two groups were significantly decreased(P<0.05),and VAS scores,joint function scores,and activity of the sustained-release tablets group were significantly lower than those of the conventional tablets group(P<0.05).Conclusion Aceclofenac Sustained-release Tablets has clinical curative effect in treatment of knee osteoarthritis,can relieve the pain of patients,improve the joint function and daily living ability of patients,which has a certain clinical application value.

关 键 词：醋氯芬酸缓释片 醋氯芬酸片 膝骨关节炎 VAS评分 关节功能评分 日常生活能力评分 

分 类 号：R977[医药卫生—药品]