2017—2019年南阳市第一人民医院感染病原菌的分布及耐药性分析  

Distribution and drug resistance of pathogenic bacteria in Nanyang First People’s Hospital from 2017 to 2019

作　　者：曹玉琳[1] 王进[2] 曾宪斌[1] CAO Yu-lin;WANG Jin;ZENG Xian-bin(Department of Laboratory Medicine,Nanyang First People’s Hospital,Nanyang 473000,China;Department of Radiology,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院检验科,河南南阳473000 [2]南阳市第一人民医院放射科,河南南阳473000

出　　处：《现代药物与临床》2020年第8期1719-1723,共5页Drugs & Clinic

基　　金：河南省卫计委科研项目(201602389)。

摘　　要：目的对2017—2019年南阳市第一人民医院感染病原菌的分布及耐药性进行分析。方法采用回顾性分析方法对2017—2019年南阳市第一人民医院感染病原菌的分布及耐药性进行分析。结果2017—2019年298例患者医院感染共有319份样本,其中以痰液居多,构成比为44.83%,2017—2019年构成比分别为46.15%、46.23%、42.20%。其次为尿液,构成比为32.92%。共检测出348株病原菌,以革兰阴性菌为主,共242株,构成比为69.54%,主要为铜绿假单胞菌和大肠埃希菌;革兰阳性菌共102株,构成比为32.18%,主要为金黄色葡萄球菌,共65株,构成比为18.68%。铜绿假单胞菌、大肠埃希菌对氨苄西林、环丙沙星、美罗培南和青霉素的耐药性较高,耐药率均在72.73%~92.68%。金黄色葡萄球菌对阿米卡星、庆大霉素、美罗培南和呋喃妥因的耐药性较高,耐药率均在75.00%以上,特别是对美罗培南的耐药率,2017年为100.00%。结论2017—2019年南阳市第一人民医院感染患者的病原菌以革兰阴性菌为主,主要病原菌对氨苄西林、环丙沙星、美罗培南抗生素的耐药性均较高。Objective To analyze the distribution and drug resistance of pathogenic bacteria in Nanyang First People’s Hospital from 2017 to 2019.Methods A retrospective survey was conducted to analyze the distribution and drug resistance of pathogenic bacteria in Nanyang First People’s Hospital from 2017 to 2019.Results A total of 298 patients with hospital infections from 2017 to 2019 had a total of 319 samples,of which the majority were sputum samples with the constituent ratio of 44.83%.And the constituent ratio of sputum samples from 2017 to 2019 were 46.15%,46.23%,and 42.20%,respectively.A total of 348 strains of pathogenic bacteria were detected,Gram-negative bacteria were 242 strains(69.54%),and main of them were Pseudomonas aeruginosa and Escherichia coli.Gram-positive bacteria were 102 strains(32.18%),and main of them were Staphylococcus aureus(65 strains)with the constituent ratio of 18.68%.P.aeruginosa and E.coli had high drug resistance against ampicillin,ciprofloxacin,meropenem,and penicillin,and the drug resistance rate were 72.73%—92.68%.S.aureus had high drug resistance against amikacin,gentamycin,meropenem,and nitrofurantoin,and the drug resistance rate were above 75.00%.Especially the drug resistance rate against meropenem was 100.00%in 2017.Conclusion From 2017 to 2019,the pathogenic bacteria in Nanyang First People’s Hospital from 2017 to 2019 are mainly Gram-negative bacteria,and the main pathogenic bacteria are highly resistant to antibacterial drugs such as ampicillin,ciprofloxacin,and meropenem.

关 键 词：抗菌药物 感染性疾病 病原菌 耐药性 

分 类 号：R978.1[医药卫生—药品]