纳米粘土锂皂石的研究现状与应用前景  

Status and application prospects of nano-clay Laponite

作　　者：樊雪敏 方善宝 陈志兴 莫水学[2] Fan Xuemin;Fang Shanbao;Chen Zhixing;Mo Shuixue(Guangxi Medical University,Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation,Guangxi Clinical Medical Research Center of Craniomaxillofacial Deformity,Guangxi Key Laboratory of Oral and Maxillofacial Surgery Diseases,Nanning 530021,Guangxi Zhuang Autonomous Region,China;Department of Orthodontics,Stomatological Hospital,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学,广西口腔颌面修复与重建研究自治区级重点实验室,广西颅颌面畸形临床医学研究中心,颌面外科疾病诊治研究重点实验室,广西壮族自治区南宁市530021 [2]广西医科大学附属口腔医院正畸科,广西壮族自治区南宁市530021

出　　处：《中国组织工程研究》2021年第10期1622-1627,共6页Chinese Journal of Tissue Engineering Research

基　　金：广西高校中青年教师科研基础能力提升项目(2019KY0100),项目负责人:方善宝;国家自然科学基金(8156030035),项目负责人:莫水学。

摘　　要：背景:纳米材料的发展是生物医学技术的重要基础,纳米粘土锂皂石是一种人工合成的纳米材料,性能优良,被广泛应用于药物输送、组织再生、3D生物打印等领域。目的:对纳米粘土锂皂石最新的应用现状及未来研究前景进行综述。方法:以中文关键词"纳米粘土、粘土、锂皂石",英文关键词"Nano-clay,clay,Laponite"在中国知网数据库、万方数据库、中国生物医学数据库及PubMed中进行文献检索,并进行进一步的筛选、归纳与总结。结果与结论:锂皂石具有独特的流变特性、导电特性、抗菌性、成组织性、良好的生物相容性等优良性能,被广泛研究应用于化工领域、药物递送领域、再生医学领域等,是一种具有广泛应用前景的纳米材料。基于锂皂石的纳米复合材料是目前锂皂石在生物医学领域的热门研究方向,自组装、多孔性、良好的生物相容性和物理性能为锂皂石纳米生物支架提供了良好的保障。需要更多基础研究来深入阐明锂皂石的作用机制,将基础研究与临床应用结合起来有助于锂皂石材料在临床安全应用。BACKGROUND: The development of nanomaterials provides a good guarantee for the development of biomedicine. Nano-clay Laponite is a synthetic nanomaterial with excellent properties. It is widely used in drug delivery, tissue regeneration, three-dimensional biological printing and other fields.OBJECTIVE: To summarize the latest application status and future research prospect of nano-clay Laponite.METHODS: With the key words of "nano-clay, clay, Laponite" in English and Chinese, we searched CNKI, Wanfang, China Biomedical Database and PubMed. We further screened and summarized.RESULTS AND CONCLUSION: Laponite has unique rheological properties, electrical conductivity, antibacterial properties, organization, good biocompatibility and other excellent properties, has been widely used in the fields of chemical industry, drug delivery, and regenerative medicine. It is a kind of nanomaterial with wide application prospect. Laponite-based nanocomposites are currently a hot research direction in the biomedical field. Self-assembly, porosity, good biocompatibility and physical properties provide a good guarantee for Laponite nano-biological scaffolds. More basic studies are needed to clarify its mechanism. Combining basic research with clinical application will help Laponite materials to be used safely in clinical practice.

关 键 词：材料 纳米材料 粘土 锂皂石 流变剂 药物递送 组织再生 生物医学 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]