神经节苷脂钠联合高压氧治疗突发性耳聋患者的效果评估  

Effect of Ganglioside Sodium Combined with Hyperbaric Oxygen on the Patients with Sudden Deafness

作　　者：陈永禄 温丽慧[2] 刘海媚 周丹 谢友琴 CHEN Yong-lu;WEN Li-hui;LIU Hai-mei;ZHOU Dan;XIE You-qin(Department of Otolaryngology,Shenzhen Hospital,Beijing University of traditional Chinese Medicine,Shenzheng,Guangdong,518172,China;Department of Otolaryngology,the second people's Hospital of Qinzhou,Qinzhou,Guangxi,535000,China)

机构地区：[1]北京中医药大学深圳医院耳鼻咽喉科,广东深圳518172 [2]广西钦州市第二人民医院耳鼻咽喉科,广西钦州535000

出　　处：《现代生物医学进展》2020年第16期3181-3184,3090,共5页Progress in Modern Biomedicine

基　　金：广东省医学科研基金立项课题(A2014598)。

摘　　要：目的:探讨神经节苷脂钠联合高压氧治疗突发性耳聋患者的疗效,并分析其对患者血清高迁移率蛋白-1(High mobility protein-1,HMGB1)、中性粒细胞激活肽-78(Neutrophil activating peptide-78,ENA-78)的影响。方法:选择我院2018年1月至2019年8月接诊的96例突发性耳聋患者,通过随机数表法将其分为观察组和对照组,每组48例。对照组在常规治疗基础上给予高压氧治疗,观察组在对照组的基础上给予神经节苷脂钠注射液治疗,两组均连续治疗2个疗程。治疗后,比较两组的临床疗效、治疗前后纯音听阈测试结果、凝血功能、血清HMGB1、ENA-78水平的变化及不良反应的发生情况。结果:治疗2个疗程后,观察组临床疗效总有效率明显高于对照组(93.75%vs79.17%),差异有统计学意义(P<0.05);观察组纯音听阈测试结果明显低于对照组[(32.14±4.94)dB vs.(37.23±5.12)dB](P<0.05),凝血酶原时间(Prothrombin time,PT)、部分活化凝血酶原时间(Partial activated prothrombin time,APTT)、凝血酶时间(Thrombin time,TT)明显短于对照组,纤维蛋白原(Fibrinogen,FIB)明显低于对照组。结论:神经节苷脂钠联合高压氧治疗突发性耳聋患者的效果显著优于单用高压氧治疗,其可有效促进听力恢复,且不增加药物不良反应,其机制可能与降低血清HMGB1、ENA-78水平有关。Objective:To study the effect of ganglioside sodium combined with hyperbaric oxygen on the patients with sudden deafness,and the mechanism of its action on serum high mobility protein-1(HMGB1)and neutrophil activating peptide-78(ENA-78)was analyzed.Methods:96 patients of sudden deafness who received therapy fromJanuary 2018 to August 2019 in our hospital were selected as research objects,according to the random number table,they were divided into the observation group and the control group,each group had 48 cases.The control group was given hyperbaric oxygen treatment on the basis of routine treatment,and the observation group was combined with ganglioside sodium injection on the basis of the control group,the 2 groups were treated for 2 courses.After treatment,the clinical efficacy,the changes of the pure tone threshold test results,goagulation function,serum HMGB1,ENA-78 levels before and after treatment and adverse reactions were compared.Results:After 2 courses of treatment,the total effective rate in the observation group was significantly higher than those in the control group(93.75%vs79.17%),the difference was statistically significant(P<0.05);the pure tone threshold test results in the observation group was significantly lower than those in the control group[(32.14±4.94)d B vs.(37.23±5.12)dB],the prothrombin time(PT),partial activated prothrombin time(APTT)and thrombin time(TT)in the observation group were significantly shorter than those in the control group,and fibrinogen(FIB)was significantly lower than those in the control group.Conclusion:The effect of ganglioside sodium combined with hyperbaric oxygen in the treatment of sudden deafness is significantly better than that of hyperbaric oxygen alone,which can effectively promote hearing recovery,and not increase adverse drug reactions,the mechanism may be related to the reduction of serum HMGB1 and ENA-78 levels.

关 键 词：突发性耳聋 高压氧 神经节苷脂钠 高迁移率蛋白-1 中性粒细胞激活肽-78 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]