基质金属蛋白酶9对糖尿病足溃疡愈合影响的研究进展  

Research Progress on the Effects of Matrix Metalloproteinase 9 on the Healing of Diabetic Foot Ulcers

作　　者：王丽芹[1] 牛香茹 何文欣 高兆虹 杨素珍 袁美琪 李艳秋[3] WANG Li-qin;NIU Xiang-ru;HE Wen-xin;GAO Zhao-hong;YANG Su-zhen;YUAN Mei-qi;LI Yan-qiu(First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin,Heiongjiang,150040,China;Graduate School,Heilongjiang University of Chinese Medicine,Harbin,Heiongjiang,150040,China;The Third Acupuncture Department of First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [3]黑龙江中医药大学附属第一医院针灸三科,黑龙江哈尔滨150040

出　　处：《现代生物医学进展》2020年第16期3197-3200,共4页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科研项目(SJYY20180469);黑龙江省高等教育综合改革试点专项项目(JG2201201260);世界中医药联合会护理专业委员会指令性课题暨江苏省高校优势学科工程南京中医药大学护理学优势学科开放课题(SZLHLA-1910);黑龙江中医药大学研究生创新科研项目立项(2019yjscx022);黑龙江中医药大学优秀创新人才支持计划资助。

摘　　要：在糖尿病足患者溃疡创面分泌物中,基质金属蛋白酶9 (matrix metalloproteinase-9,MMP-9)过高是预测糖尿病足的发生及足溃疡难愈的主要指标,其可能的机制包括:高水平MMP-9降低VEGF的表达、抑制成纤维细胞的生物学行为影响糖尿病足溃疡愈合;失衡的MMP-9/TIMP-1比值影响糖尿病足溃疡愈合。选择性MMP-9抑制剂(包括小分子抑制剂、高级伤口辅料抑制剂、基于干扰基因水平表达的RNA抑制剂)可以作为促进糖尿病足溃疡愈合的手段,但仍需大样本、多中心随机对照试验以及长期随访进一步验证其疗效及安全性。现查阅近年来涉及MMP-9和糖尿病足溃疡相关的文献,综述MMP-9对糖尿病足溃疡愈合的影响及其机制研究进展。In the ulcer wounds of diabetic foot patients,excessive matrix metalloproteinase-9(MMP-9)is the main indicator for predicting the occurrence of diabetic foot and the difficulty of foot ulcer.The possible mechanisms include:high level of MMP-9 reduces VEGF expression and inhibits fibroblast formation.The biological behavior of the cells affects diabetic foot ulcer(DFU)healing;the imbalanced MMP-9/TIMP-1 ratio affects DFU healing.Selective MMP-9 inhibitors(including small molecule inhibitors,advanced wound adjuvant inhibitors,RNA inhibitors based on interfering gene level expression)can be used as a means of promoting DFU healing,but large-sample,multicenter randomized controlled trials are still needed.Long-term follow-up further verified the efficacy and safety.The literature related to MMP-9 and DFU in recent years was reviewed and summarized.To review the effects of MMP-9 on the healing of DFU and its mechanism.

关 键 词：基质金属蛋白酶9 选择性基质金属蛋白酶9抑制剂 糖尿病足 溃疡 创面愈合 

分 类 号：R587.2[医药卫生—内分泌]