胺碘酮联合美托洛尔治疗快速心律失常的疗效及安全性分析  

Analysis of the Efficacy and Safety of Amiodarone Combined with Metoprolol in the Treatment of Tachyarrhythmia

作　　者：王飞[1] WANG Fei(Department of Cardiology,Laiwu Central Hospital,Xinwen Mining Group,Jinan,Shandong Province,271103 China)

机构地区：[1]新汶矿业集团莱芜中心医院心血管一科,山东济南271103

出　　处：《系统医学》2020年第15期41-43,共3页Systems Medicine

摘　　要：目的探究胺碘酮联合美托洛尔治疗快速心律失常的临床效果以及用药安全性,进一步提升临床对这一病症的治疗效果。方法共选取2018年9月—2019年11月该科室82例快速心律失常的患者进行该次研究,选用电脑随机数字方式分组,对比组41例,研究组41例,对比组予以胺碘酮进行治疗,研究组予以胺碘酮联合美托洛尔进行治疗,分析两组的临床治疗效果与用药安全性。结果数据结果显示:研究组的收缩压为(130.84±9.76)mmHg,对比组为(149.21±10.51)mmHg(t=8.200,P=0.000);研究组的舒张压为(91.63±5.57)mmHg,对比组为(98.11±6.42)mmHg(t=4.881,P=0.000),研究组的心率为(91.54±12.36)次/min,对比组为(99.62±13.62)次/min(t=2.812,P=0.006),研究组能够更好地改善收缩压、舒张压以及心率,对比差异有统计学意义(P<0.05);研究组发生2例血压下降,1例心动过缓,总发生率为7.32%,对比组发生1例血压下降,1例心动过缓,总发生率为4.88%,临床不良反应发生率两组对比差异无统计学意义(χ^2=0.213,P=0.644 P>0.05)。结论在快速心律失常患者中进行胺碘酮联合美托洛尔治疗,能够良好地改善患者的血压与心率状况,且与但用胺碘酮治疗不良反应发生率无明显差异,在临床中的整体运用价值较高。Objective To explore the clinical effect and safety of amiodarone combined with metoprolol in the treatment of tachyarrhythmia,and to further improve the clinical therapeutic effect of this disease.Methods A total of 82 patients with tachyarrhythmia from September 2018 to November 2019 in the department were selected for this study,using computer random number grouping,41 cases in the comparison group,41 cases in the study group,the control group was treated with amiodarone,and the study group was treated with amiodarone in combination with metoprolol,and the clinical treatment effect and safety of medication were analyzed in the two groups.Results The data showed that the systolic blood pressure in the study group was(130.84±9.76)mmHg,the control group was(149.21±10.51)mmHg(t=8.200,P=0.000);the diastolic blood pressure in the study group was(91.63±5.57)mmHg,the control group was(98.11±6.42)mmHg(t=4.881,P=0.000),the heart rate of the study group was(91.54±12.36)beats/min,the comparison group was(99.62±13.62)beats/min(t=2.812,P=0.006),the study group could better improve systolic blood pressure,diastolic blood pressure and heart rate,the difference was statistically significant(P<0.05);2 blood pressure drops occurred in the study group,1 patient suffered from bradycardia,total occurance rate was 7.32%.In the control group,there was 1 case of blood pressure reduction and 1 case of bradycardia.The total incidence rate was 4.88%.There was no statistically significant difference in the incidence of clinical adverse reactions between the two groups(χ^2=0.213,P=0.644,P>0.05).Conclusion The treatment of amiodarone combined with metoprolol in patients with tachyarrhythmia can improve the patient's blood pressure and heart rate,and there is no significant difference in the incidence of adverse reactions with but treatment with amiodarone.The overall application value is high.

关 键 词：胺碘酮 美托洛尔 快速心律失常 临床效果 用药安全性 

分 类 号：R4[医药卫生—临床医学]