固本平哮汤联合西药对哮喘缓解期肺肾气虚证患者肺功能及血清T淋巴细胞亚群的影响  

Effects of Guben Pingxiao Decoction combined with western medicine on lung function and serum T lymphocyte subsets in patients with lung-renal-qi-deficiency syndrome during asthma remission period

作　　者：杨永[1] 徐靖华[1] 郑珂[1] 王勃[1] 李跃飞[1] 李圣[1] Yang Yong;Xu Jinghua;Zheng Ke;Wang Bo;Li Yuefei;Li Sheng(Department of Emergency,Medicine Hospital Subsidiary Fourth,Liaoning University of Traditional Chinese Medicine,Shenyang 110101,China)

机构地区：[1]辽宁中医药大学附属第四医院急诊科,沈阳110101

出　　处：《保健医学研究与实践》2020年第4期26-31,共6页Health Medicine Research and Practice

基　　金：辽宁省省直医院改革重点临床科室诊疗能力建设项目〔辽财指社[2015]458号〕。

摘　　要：目的探讨固本平哮汤联合西药对哮喘缓解期肺肾气虚证患者肺功能及血清T淋巴细胞亚群的影响。方法选取2017年2月-2019年3月沈阳市某医院收治的80例哮喘缓解期肺肾气虚证患者为研究对象,采用随机数字表法将患者分为观察组和对照组,每组40例。对照组患者给予布地奈德吸入剂吸入治疗,观察组患者在对照组治疗基础上给予固本平哮汤。治疗12周时,比较2组患者的治疗效果及不良反应发生情况;比较2组患者治疗前后临床症状积分、肺功能[第1秒用力呼气容积占用力肺活量比值(FEV1/FVC)、第1秒用力呼气容积占预计值百分比(FEV1%)以及最大呼气流速占正常预计值的百分比(PEF%)]变化情况、血清T淋巴细胞亚群[CD4^+及CD8^+细胞及CD4^+/CD8^+]水平。结果对照组患者治疗总有效30例(临床控制6例、显效9例、有效15例),治疗总有效率为75.00%;观察组患者治疗总有效37例(临床控制7例、显效16例、有效14例),治疗总有效率为92.50%;观察组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者临床症状(喘息胸闷、畏风寒、神疲乏力、腰膝酸软、耳鸣头昏)积分比较,差异均无统计学意义(P>0.05);治疗后,2组患者临床症状(喘息胸闷、畏风寒、神疲乏力、腰膝酸软、耳鸣头昏)积分均低于治疗前,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者FEV1/FVC,FEV1%及PEF%比较,差异均无统计学意义(P>0.05);治疗后,2组患者FEV1/FVC,FEV1%及PEF%均高于对照组,且观察组患者高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者CD4^+,CD8^+及CD4^+/CD8^+水平比较,差异均无统计学意义(P>0.05);治疗后,2组患者CD4^+及CD4^+/CD8^+水平均高于治疗前,且观察组患者高于对照组,差异均有统计学意义(P<0.05);治疗后,2组患者CD8^+水平低于治疗前,且观察组患者低于对照组,差异有统计学意义(P<Objective To investigate the effect of Guben Pingxiao Decoction combined with western medicine on lung function and serum T lymphocyte subsets in patients with lung-kidney deficiency syndrome during asthma remission.Methods From February 2017 to March 2019,80 patients with lung-kidney deficiency syndrome in asthma remission who were treated in a hospital in Shenyang City were selected as the research subjects.The patients were divided into observation group and control group by random number table method,with 40 cases in each group.Patients in the control group were given budesonide inhalation inhalation treatment.Patients in the observation group were given Guben Pingxiao Decoction on the basis of treatment in the control group.Both groups of patients continued treatment for 12 weeks.The treatment effects and adverse reactions of the two groups were compared;the clinical symptom score,lung function changes,and serum T lymphocyte subgroup levels were compared between the two groups.Results A total of 30 patients in the control group were effective in treatment(6 cases were clinically controlled,9 cases were markedly effective,15 cases were effective),and the total effective rate was 75.00%.The observation group had a total effective treatment of 37 patients(7 clinically controlled,16 significantly effective,and 14 effective),and the total effective rate was 92.50%.The treatment efficiency of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the clinical symptoms(wheezing,chest tightness,chills,coldness,fatigue,waist and knee weakness,tinnitus and dizziness)of the two groups of patients before treatment(P>0.05).After treatment,the scores of clinical symptoms(wheezing,chest tightness,chills,fatigue,fatigue of the waist and knees,and tinnitus and dizziness)in the two groups were lower than before treatment,and the observation group was significantly lower than the control group.(P<0.05).There was no signific

关 键 词：哮喘缓解期 固本平哮汤 T淋巴细胞 肺功能指标 免疫功能 疗效观察 

分 类 号：R259[医药卫生—中西医结合]