散血明目片联合康柏西普对糖尿病视网膜病变并发玻璃体积血患者视网膜电图明适应的影响  

A Study on the Effect of Sanxue Mingmu Tablet Combined with Compaccip on Electroretinogram Adaptation in Patients with Diabetic Retinopathy Complicated with Vitreous Hemorrhage

作　　者：刘培 李书楠 付美林[1,2] 彭俊[2] 陈向东[2] 蒋鹏飞[1] 彭清华[1,2] Liu Pei;Li Shunan;Fu Meilin;Peng Jun;Chen Xiangdong;Jiang Pengfei;Peng Qinghua(Hunan University of Chinese Medicine,Changsha Hunan 410208;The First Affiliated hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《现代中医药》2020年第5期53-58,共6页Modern Chinese Medicine

基　　金：国家自然科学基金面上资助项目(81804150,81574031);中医药防治五官科疾病湖南省重点实验室建设项目(2017TP1018);国家中医药管理局中医眼科学重点学科建设项目(ZK1801YK015);湖南省研究生科研创新项目(CX2018B497)。

摘　　要：目的观察散血明目片对糖尿病视网膜病变(diabetic retinopathy,DR)并发玻璃体积血(vitreous hemorrhage,VH)患者视网膜电图的影响。方法 60例(85眼)DR并发VH患者随机数字表法分为两组,对照组30例(42眼)行玻璃体切除治疗,术后1mo玻璃体腔注射康柏西普,治疗组30例(43眼)在对照组的基础上于玻璃体切除手术后加用散血明目片口服治疗。治疗4mo后,观察两组患者最佳矫正视力(best corrected visual acuity,BCVA)、视网膜电图(electroretinogram,ERG)、光学相干断层成像(Optical coherence tomography,OCT)检测两组患者黄斑中心凹厚度(central macular thickness,CMT)情况。结果两组患者治疗前后不同时间BCVA差异有统计学意义(P<0.001),治疗后1mo两组患者BCVA相比,差异无统计学意义(P>0.05),治疗后2mo、3mo、4mo两组患者BCVA相比,差异均有统计学意义(P<0.05);两组患者治疗前后不同时间明适应a、b波振幅差异均有统计学意义(P<0.05),两组患者治疗前后不同时间明适应a波潜伏时差异均有统计学意义(P<0.05),治疗后3mo、4mo两组患者明适应b波振幅相比,差异均有统计学意义(P<0.05);两组患者治疗前后不同时间CMT差异有统计学意义(P<0.001),治疗后1mo两组患者CMT相比,差异无统计学意义(P>0.05),治疗后2mo、3mo、4mo两组患者CMT相比,差异均有统计学意义(P<0.05)。结论散血明目片联合康柏西普较单纯康柏西普治疗糖尿病视网膜病变并发玻璃体积血,能更好的减轻视网膜水肿,提高视力及明适应a、b波振,降低CMT、明适应a、b潜伏时。Objective To observe the influence of Sanxue Mingmu Tablet on diabetic retinopathy(DR) patients with vitreous hemorrhage(VH). Methods Sixty patients(85 eyes) with DR complicated with VH were divided into two groups by random number table method. 30 patients(42 eyes) in the control group received vitrectomy for treatment, 1 MO intravitreal injection of Compaccip, and 30 patients(43 eyes) in the treatment group were treated by oral administration of Sanxue Mingmu tablets after vitrectomy on the basis of the control group. Several BCVA(best corrected visual acuity), electroretinogram(ERG), and OCT(Optical coherence tomography) were observed to test the central macular thickness(CMT) of the two groups after treatment of 4 mo. Result The BCVA of patients in the two groups at different times before and after treatment showed statistically significant difference(P<0.001);after treatment, the BCVA of patients in 1 mo group showed no statistically significant difference(P>0.05);after treatment, the BCVA of patients in 2 mo group, 3 mo group and 4 mo group showed statistically significant difference(P<0.05). In the two groups before and after treatment in patients with different time, light adaptation of a and b wave amplitude difference had statistical significance(P<0.05), the two groups before and after treatment in patients with different time light adaptation, the wave of latent difference had statistical significance(P<0.05). After treatment 3 mo and 4 mo, compared two groups of patients b wave amplitude of light adaptation, differences were statistically significant(P<0.05);There were statistically significant differences in CMT between the two groups at different times before and after treatment(P<0.001), no statistically significant differences in CMT between the two groups at 1 mo after treatment(P>0.05), and there were statistically significant differences in CMT between the two groups at 2 mo, 3 mo and 4 mo after treatment(P<0.05). Conclusion Compared with the treatment of diabetic retinopathy complicated by vi

关 键 词：散血明目片 活血利水 糖尿病视网膜病变 玻璃体积血 康柏西普 视网膜电图 

分 类 号：R285.6[医药卫生—中药学]