异动症与多巴胺通路基因的相关性研究进展  

Advances in Research on the Relationship between Levodopa-induced Dyskinesias and Dopamine Pathway Genes

作　　者：计敏[1] 孙慧敏 张克忠[1] JI Min;SUN Hui-min;ZHANG Ke-zhong(Department of Neurology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院神经内科,南京210029

出　　处：《中国临床神经科学》2020年第4期462-466,480,共6页Chinese Journal of Clinical Neurosciences

基　　金：基于多巴胺通路的左旋多巴诱导异动症相关脑网络机制研究(编号:81671258)。

摘　　要：异动症是帕金森病患者长期接受多巴胺药物治疗后出现的一种运动并发症,其危险因素和致病机制尚不清楚。近年来发现,遗传变异是异动症发病的重要因素之一,多巴胺通路基因的研究最为广泛。多巴胺受体基因、多巴胺转运体基因、儿茶酚-O-甲基转移酶基因、单胺氧化酶B基因与异动症的发病时间和类型有关,针对这些基因进一步开展研究,有助于理解异动症发生的个体差异和相关机制,寻找预测异动症的生物标记物。文中就多巴胺通路基因与异动症之间的相关性研究进行综述。Dyskinesia is a kind of motor complication of Parkinson’s disease patients after longterm treatment with dopaminergic drugs.Its risk factors and pathogenesis are not clear.In recent years,it has been found that genetic variants or polymorphisms is one of the important factors in the pathogenesis of dyskinesia,and dopaminergic pathway genes are the most widely studied.Dopamine receptor gene,dopamine transporter gene,catechol-O-methyltransferase gene and monoamine oxidase B gene are related to the onset time and type of dyskinesia.Further research on these genes will help to understand the individual differences and related mechanisms of dyskinesia,and find biomarkers to predict dyskinesia.The correlation between these genes and dyskinesia was reviewed.

关 键 词：异动症 帕金森病 多巴胺通路 基因 

分 类 号：R4[医药卫生—临床医学] R742.5