血流储备分数(FFR)在重度颈内动脉狭窄中的实验研究  

The application of fractional flow reserve (FFR) in severe internal carotid artery stenosis

作　　者：柯伟[1] 李文澜[2] 邓小容 Ke Wei;Li Wenlan;Deng Xiaorong(Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060;不详)

机构地区：[1]武汉大学人民医院神经内科,430060 [2]武汉大学人民医院麻醉科,430060 [3]湖北省第三人民医院神经内科

出　　处：《卒中与神经疾病》2020年第4期513-516,共4页Stroke and Nervous Diseases

基　　金：血流储备分数(FFR)中重度颈内动脉狭窄中的实验研究(WJ2015MB127)。

摘　　要：目的探讨血流储备分数(Fractional flow reserve,FFR)在颈内动脉狭窄血管内介入治疗评估中的意义。方法将50只兔子随机分为正常组(n=10)和模型组(重度颈内动脉狭窄组)(n=40),并进行编号,采用结扎法建立兔颈内动脉重度狭窄的模型,模型组采用DSA的方法评估血管狭窄率及模型的可靠性;测得重度狭窄颈内动脉的狭窄近端压力(Pa)、狭窄远端压力(Pd)的数值,计算出Ic-FFR(Pd/Pa)值,并得出模型组Pa、Pd值与时间(s)的变化曲线;采用回归分析颈内动脉狭窄率与Ic-FFR的相关性。结果 40例中35例(87.5%)符合颈内动脉重度狭窄,5例(12.5%)没有达到重度狭窄的标准。模型组Pd、Pa的值在20 s达到最大值,持续维持一段时间,最大值后40 s内Pd、Pa的值未见明显变化。正常组Ic-FFR值为1。模型组35例颈内动脉重度狭窄中测得Pa值为(103.029±5.404)mmHg,中位数为104 mmHg;Pd值为(87.882±5.031)mmHg,中位数为88.110 mmHg;Ic-FFR值为0.853±0.026,中位数为0.86;颈内动脉狭窄率与Ic-FFR呈负相关(r=-0.65,P<0.05)。结论颈内动脉血流储备分数(Internal carotid artery fractional flow reserve,Ic-FFR)为颈动脉狭窄血管内介入治疗评估提供一定的理论基础。Objective To investigate the feasibility of fractional flow reserve(FFR) in the treatment of internal carotid artery stenosis. Methods Fifty rabbits were randomly divided into normal group(n=10) and model group(n=40) and numbered. The model group was severe internal carotid artery stenosis group(n=40). A rabbit model of severe internal carotid artery stenosis was established by ligation method. The proximal pressure(Pa) and the dista pressure(Pd) of internal carotid artery stenosis were measured, and the FFR(Pd/Pa) was calculated. The change curves of Pa, Pd and time(S) in the model group were obtained. The correlation between the rate of internal carotid stenosis and Ic-FFR was analyzed by regression. Results In the model group DSA was used to evaluate the stenosis rate and the reliability of the model. Among the 40 cases, 35 cases(87.5%) met the criteria of severe internal carotid artery stenosis, and 5 cases(12.5%) did not meet the criteria of severe stenosis. The Pd and Pa in the model group reached the maximum in 20 s, which was maintained for a period of time, and there was no significant change within 40 s after the maximum. The internal carotid artery fractional flow reserve(Ic-FFR) of normal group was 1.0. The Pa of model group was(103.029±5.404) mmHg and the median was 104.000 mmHg mmHg. The Pd of model group was value was(87.882±5.031) mmHg, and the median was 88.110 mmHg. The Ic-FFR(Pd/Pa) was 0.853±0.026, the median was 0.86. The rate of internal carotid artery stenosis was negatively correlated with Ic-FFR(r=-0.65,P<0.05). Conclusion The Ic-FFR provided a basic theory in the treatment of internal carotid artery stenosis.

关 键 词：颈内动脉 狭窄 血流储备分数 

分 类 号：R543.5[医药卫生—心血管疾病]