LncRNA和RBP在免疫调节中的研究进展  

Research progress of LncRNA and RBP in immune regulation

作　　者：雷艳婷 李兆瀛 孙博[1] 汪嘉麒 李呼伦(指导)[1] LEI Yan-Ting;LI Zhao-Ying;SUN Bo;WANG Jia-Qi;LI Hu-Lun(Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学,哈尔滨150081

出　　处：《中国免疫学杂志》2020年第15期1896-1901,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(No.81571168,No.81870955)资助。

摘　　要：免疫细胞的分化和功能受多种因素调控,长链非编码RNA(LncRNA)是免疫系统的重要调控者。研究表明LncRNA分子具有较高的谱系特异性并调控免疫细胞的分化和功能,多数LncRNA分子需要与RNA结合蛋白(RBP)结合并通过多种方式发挥调节功能。为更好地总结LncRNA分子与RBP在免疫细胞发育、分化及效应功能中的研究进展,本文从LncRNA分子与RBP的发展趋势、RBP属性分类和两者免疫调节作用3方面梳理了2010年以来LncRNA分子与RBP在免疫细胞中的研究进展进行综述。Differentiation and function of immune cells are regulated by many factors,and LncRNA is an important regulator of immune system.Studies have shown that LncRNA has a high lineage-specific pattern and regulate differentiation and function of immune cells,the majority regulates immune system by combining with RBP.In order to summarize research progresses of LncRNA and RBP in development,differentiation and effector function of immune cells,we reviewed research progresses of LncRNA and RBP in immune cells since 2010 in three aspects:development trend of LncRNA and RBP,attributeclassification of RBPs and immune regulatory functions they play.

关 键 词：长链非编码RNA RNA结合蛋白 发展趋势 RBP分类 免疫调节 

分 类 号：R392[医药卫生—免疫学]