浅述水溶性Cu卟啉配合物体外抗肿瘤活性研究  

Progress on Antitumor in Vitro of Water Soluble Porphyrin Base Cu(Ⅱ)Complexes

作　　者：武彧 刘家成[2] WU Yu;LIU Jia-cheng(School of Chemistry and Chemical Engineering,Qiannan Normal University for Nationalities,Guizhou Duyun 558000;College of Chemistry and Chemical Engineering,Northwest Normal University,Gansu Lanzhou 730070,China)

机构地区：[1]黔南民族师范学院化学化工学院,贵州都匀558000 [2]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《广州化工》2020年第18期9-12,15,共5页GuangZhou Chemical Industry

基　　金：黔南州科技计划项目(项目编号:黔南科合(2018)07号);黔南民族师范学院科研创新基金重大专项计划项目(QNSY2018BS020)。

摘　　要：恶性肿瘤的治疗是当下研究热点,水溶性Cu卟啉配合物具有较好的生物活性可作为新一类抗癌药物引起人们的广泛关注。本文首先介绍了近些年水溶性卟啉化合物抗肿瘤研究概况,其次总结了本组设计合成的含有酰腙、席夫碱类水溶性Cu卟啉配合物。并通过流式细胞术测试周期法研究了对癌细胞的作用机制,研究结果表明这两类基团具有较好的抗癌活性,这为水溶性卟啉化合物在医学和生命科学方面的发展提供一定的研究基础。The treatment of malignant tumors is a hot topic at current research.Water-soluble Cu porphyrin complexes,which can be used as new classes of anti-cancer drugs have caused widespread concern.The antitumor research of water-soluble porphyrin compounds in recent years was firstly introduced,and then the water-soluble Cu porphyrin complexes containing acylhydrazone and Schiff base were summarized.The flow cytometer test cycle method was used to study the mechanism of action on cancer cells.The results showed that these two types of groups had good anticancer activity,and their anticancer activity was significantly improved.This provides a certain research basis for the development of water-soluble porphyrin compounds in medicine and life sciences.

关 键 词：水溶性卟啉 酰腙 席夫碱 Cu配合物 体外抗肿瘤 

分 类 号：O641.4[理学—物理化学]