IL-38的生物学特性及其在肺部疾病中作用的研究进展  

Advance in biological properties of IL-38 and its role in pulmonary diseases

作　　者：徐唯傑 马俊[2] 李明才[1] XU Wei-jie;MA Jun;LI Ming-cai(Medical School of Ningbo University,Ningbo 315211,China;Shanghai Pulmonary Hospital,Shanghai 200003,China)

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]上海市肺科医院,上海200003

出　　处：《中国病理生理杂志》2020年第9期1715-1720,共6页Chinese Journal of Pathophysiology

基　　金：浙江省自然科学基金资助项目(No.LY17H010001,No.LY18H010003)。

摘　　要：白细胞介素38(interleukin-38,IL-38)是IL-1家族(IL-1 family,IL-1F)中最新发现的细胞因子,隶属于IL-36亚家族。它最早由两个独立科研小组于2001年发现的,分别被命名为IL-1HY2和IL-1F10[1-2]。IL-38的编码基因位于人类染色体2q13-14.1上,编码IL-1受体拮抗剂(IL-1 receptor antago⁃nist,IL-1Ra)和IL-36Ra的基因之间[2]。Interleukin-38(IL-38)is the most recently discovered cytokine of the IL-1 family and is an IL-36 receptor inhibitor.IL-38 is mainly expressed in human immune organs and associated with a variety of diseases.In the process of apoptosis and necrosis caused by injury or inflammation,researchers have studied quiet a lot about the kinase,cleavage sites,activity regulatory mechanism,signal transduction ligand,transduction mode and potential receptors of IL-38,but many mechanisms are still unknown.This article reviews the role of IL-38 in the pathogenesis and progression of lung tumors,asthma and interstitial lung disease.We also discussed the role of IL-38 in the treatment of these diseases,the possible relationship between IL-38 and tuberculosis,and the direction of future studies on the mechanism of IL-38 ac tion.

关 键 词：白细胞介素38 肺癌 哮喘 间质性肺病 肺结核 

分 类 号：R563[医药卫生—呼吸系统] R363[医药卫生—内科学]