CD49a分子研究进展  

Research progress of CD49a

作　　者：张彧 田志刚[1] 孙汭[1] 郑晓东[1] ZHANG Yu;TIAN Zhi-Gang;SUN Rui;ZHENG Xiao-Dong(Institute of Immunology,University of Science and Technology of China,Hefei 230027,China)

机构地区：[1]中国科学技术大学免疫学研究所,合肥230027

出　　处：《中国免疫学杂志》2020年第13期1537-1544,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81788101,91542000)资助。

摘　　要：CD49a是α1β1整联蛋白的α链,表达于间充质细胞、免疫细胞、内皮细胞及肿瘤细胞等细胞表面。作为黏附分子,CD49a的主要功能为介导细胞对细胞外基质的黏附。近年研究发现,CD49a也是组织驻留淋巴细胞的重要标志。除介导细胞黏附外,CD49a还可调节机体免疫应答,且与肿瘤进展密切相关。本文对CD49a在不同淋巴细胞上介导的黏附作用、组织驻留作用、对淋巴细胞功能状态的调节作用及其与肿瘤发生发展的关系进行综述。CD49a is theαchain ofα1β1 integrin and expressed on surfaces of mesenchymal cells,lymphocytes,endothelial cells,tumor cells and so on.As an adhesion molecule,the function of CD49a is to mediate cell adhesion to the extracellular matrix.Recent research found that CD49a is an important marker of tissue-resident lymphocytes.Expect for adhesion,CD49a can regulate the immune response and closely relate to tumor progression.This article will review adhesion to different lymphocytes,tissue retention,regulation of lymphocytes function of CD49a as well as its relationship with tumor genisis and development.

关 键 词：CD49a 黏附 免疫调节 肿瘤 

分 类 号：R392[医药卫生—免疫学]