松果体素在辅助生殖技术中的研究进展  

Research Progress of Melatonin in Assisted Reproductive Technology

作　　者：谢庆娥 王梦瑶 梁谭 刘雅静(审校) XIE Qing-e;WANG Meng-yao;LIANG Tan;LIU Ya-jing(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Histology and Embryology,Anhui Medical University,Hefei 230032,China;First Clinical Medical College,Anhui Medical University,Hefei 230032,China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Hefei 230032,China)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230022 [2]安徽医科大学组织学与胚胎学教研室 [3]安徽医科大学第一临床学院 [4]国家卫生健康委配子及生殖道异常研究重点实验室

出　　处：《国际生殖健康／计划生育杂志》2020年第5期397-400,406,共5页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金面上项目(81771653);安徽省高校优秀青年人才支持计划重点项目(gxyqZD2017031)。

摘　　要：松果体素是一种独特的抗氧化剂,与其受体存在于多种组织及细胞中,可通过与其高亲和性的跨膜受体和核内受体结合发挥一系列生物学效应,也可以通过直接清除活性氧簇(ROS)或者激活抗氧化酶发挥独特的抗氧化保护作用,从而对组织和细胞起保护作用。辅助生殖技术(ART)的关键因素之一是配子和胚胎的质量,而卵母细胞和胚胎的退化和死亡是影响ART成功率最关键的因素。松果体素不仅可以促进人未成熟卵母细胞的成熟,提高卵母细胞质量,改善胚胎的发育,而且对卵巢颗粒细胞和精子也有一定的保护作用。综述松果体素对辅助生殖技术中卵母细胞、胚胎、卵巢颗粒细胞和精子保护作用的研究进展。Melatonin as a unique antioxidant,and its receptors,exist in multiple tissues or cells.Melatonin exerts a series of biological effects not only through the activation of melatonin receptors including high-affinity transmembrane receptor and nuclear receptor,but also through the unique antioxidant protection by directly removing reactive oxygen species(ROS)or by activating antioxidative enzymes.One of the key factors of assisted reproductive technology(ART)is the quality of gametes and embryos.However,the degeneration and death of oocytes and embryos are the most critical factors affecting the success rate of ART.Melatonin can not only promote the maturation of immature oocytes,improve the quality of oocytes and the development of embryos,but also protect ovarian granulosa cells and sperm after freezing and thawing.In this paper,we review the research progress of the protective effect of melatonin on oocytes,embryos,ovarian granulosa cells and sperm in ART.

关 键 词：褪黑激素 抗氧化剂 生殖技术 辅助 卵母细胞 精子 胚胎发育 活性氧 

分 类 号：R714.8[医药卫生—妇产科学]