Vasorelaxant effects of 50 commonly used traditional herbal prescriptions on isolated rat aortic rings  

作　　者：Bumjung Kim Cheolmin Jo Somin Lee Hanna Choi Kwang-Woo Kim Inhye Ham Ho-Young Choi Kyungjin Lee 

机构地区：[1]Department of Oriental Health Management,Kyung Hee Cyber University,Seoul 02447,Republic of Korea [2]Department of Herbal pharmacology,College of Korean Medicine,Kyung Hee University,Seoul 02447,Republic of Korea [3]Department of Herbal pharmacology,Graduate School,Kyung Hee University,Seoul 02447,Republic of Korea [4]Department of Biomedical Science and Technology,Graduate School,Kyung Hee University,Seoul 02447,Republic of Korea

出　　处：《Journal of Traditional Chinese Medicine》2020年第4期629-639,共11页中医杂志（英文版）

基　　金：the'Evaluation of Herb-Drug Interactions(K16252)'from the Korea Institute of Oriental Medicine(KIOM)。

摘　　要：OBJECTIVE:To investigate the vasorelaxant activities of 50 common traditional herbal prescriptions(THPs)on isolated rat aortic rings.METHODS:An electric extractor was used to extract THPs.Rat aortic rings were precontracted using phenylephrine in organ chambers containing Krebs-Henseleit solution.Decoctions of THPs were added in increasing concentrations(10-1000μg/mL)to investigate vasorelaxant activities.The vasorelaxant effects of THPs were calculated as percentage of contraction in response to phenylephrine.RESULTS:Several THPs such as Tianwangbuxin Dan,Banxiaxiexin Tang,and Mahuang Tang,significantly relaxed precontracted aortic rings.In contrast,Xiaochaihu Tang,Shensuyin,and Guizhifuling Wan significantly contracted aortic rings.Furthermore,these THPs increasingly relaxed or contracted aortic rings relaxed by amlodipine.CONCLUSION:Our findings suggest that hypertension can be treated using THPs.However some THPs can counteract treatment of hypertension.Further studies should be developed on use of THPs for treatment of hypertension are critical,and guidelines for use of traditional herbal medicines to treat hypertension.

关 键 词：HYPERTENSION VASODILATION VASOCONSTRICTION Herbal medicine 

分 类 号：R285.5[医药卫生—中药学]