A Mother-to-Child Transmission Study in Nigeria:The Impact of Maternal HIV Infection and HAART on Plasma Immunoglobulins,Cytokine Profiles and Infant Outcome  

作　　者：Chinwe O.Ewenighi-Amankwah Charles Chinedum Onyenekwe Ogochukwu Udemba Patience Muogbo Lijun Rong 

机构地区：[1]Department of Medical Laboratory Science,Ebonyi State University,Abakaliki 480214,Nigeria [2]Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,IL 60612,USA [3]Department of Medical Laboratory Science,Faculty of Health Science and Technology,Nnamdi Azikiwe University,Awka 5025,Nigeria [4]Laboratory Unit,Mother of Christ Specialist Hospital,Ogui,Enugu 400252,Nigeria [5]Monitoring and Evaluation Unit,ART Department,Mother of Christ Specialist Hospital,Ogui,Enugu 400252,Nigeria

出　　处：《Virologica Sinica》2020年第4期468-477,共10页中国病毒学（英文版）

摘　　要：Prevention of mother-to-child transmission(PMTCT)of HIV with highly active antiretroviral therapy(HARRT)allows the HIV^+pregnant mothers to have vaginal delivery and breastfeed.Here we investigated the maternal plasma immunoglobulin,cytokine secretion and the outcome of the exposed infants among the HIV^+HAART treated pregnan women in Nigeria.In this study,different plasma immunoglobulins and cytokines were measured in the HIV^+HAART treated pregnant mothers.Pooled culture supernatants of B and T lymphocytes showed lower levels of IFN-γ,IL-10 and IL-4.There were lower IFN-γand IL-10 secretions at 1st trimester;however,IL-10 continued to be lower throughout 2nd and 3rd trimesters.TNF-αsecretion significantly decreased as pregnancy progressed to term.There were high plasma IgG and low IgM in the HIV^+HAART treated pregnant women.Plasma IgG was high during 1st and 3rd trimesters.After one year of follow up,all the exposed children were seronegative for HIV-1 and HIV-2.Vaginal delivery and breastfeeding among HIV^+HAART treated mothers have shown to be safe.The use of HAART by the infected mothers and the use of septrin and niverapin by the exposed infants prevented mother to-child transmission of HIV.

关 键 词：Human immunodeficiency virus(HIV) Prevention from mother-to-child transmission(PMTCT) Highly active antiretroviral therapy(HAART) Lymphocyte stimulation MITOGEN Cytokine IMMUNOGLOBULINS 

分 类 号：R512.91[医药卫生—内科学]