承德市妊娠晚期妇女感染HPV分型危险因素及分娩结局的相关性分析  

Analysis of the types of HPV infection,risk factors for a persistent infection,and their correlation with the outcomes of delivery in Chengde

作　　者：崔彭华[1] 张玉娟[1] 韩淑玉 高秀娟[1] 李志艳 CUI Peng-hua;ZHANG Yu-juan;HAN Shu-yu;GAO Xiu-juan;LI Zhi-yan(Gyecology,Chengde Medical College Hospital,Chengde,Hebei,China 067000)

机构地区：[1]承德医学院附属医院妇产科,河北承德067000

出　　处：《中国病原生物学杂志》2020年第8期959-962,共4页Journal of Pathogen Biology

基　　金：承德市科学技术研究与发展项目(No.201801A030)。

摘　　要：目的检测承德市妊娠晚期妇女感染人类乳头瘤病毒(HPV)类型,调查相关感染因素,分析HPV感染与分娩结局的关系。方法选择2013年1月~2017年12月在本院妇科门诊经治并进行模式液基薄层细胞学技术(TCT)及HPV筛查的患者4225例,确诊为HPV感染妊娠晚期妇女268例,检测HPV类型,比较高危型和低危型HPV感染患者及健康对照组孕妇分娩结局。所有患者随访2年,观察HPV持续感染情况,并通过Logistic回归法分析HPV持续感染发生的独立危险因素。结果268例HPV感染者共检出9种HPV基因型,其中高危型HPV感染229例,以HPV16感染多见(39.18%),HPV18、HPV52感染分别占13.80%和13.06%;低危型HPV感染39例,以HPV6、HPV11多见,分别占6.72%和5.97%。Logistic回归分析显示,年龄20~30岁,患有甲状腺疾病和宫颈炎为HPV持续感染的独立危险因素(P<0.05)。高危HPV感染组、低危HPV感染组及健康对照组产妇胎膜早破、早产、新生儿呼吸窘迫综合征、产后出血等的发生率差异无统计学(P>0.05)。结论承德市妊娠晚期妇女感染高危型HPV以HPV16为主,持续感染率较高,但HPV感染与妊娠结局无直接关系。年龄20~30岁、患有甲状腺疾病和宫颈炎为妇女妊娠晚期高危型HPV感染危险因素,可为HPV感染的预防提供参考。Objectives To detect the type of human papillomavirus(HPV)infection in women in late pregnancy in the City of Chengde,to investigate the factors for development of an HPV infection in women in late pregnancy in this area,and to analyze the relationship between HPV infection and delivery outcomes. Methods Subjects were 4,225 Gynecology outpatients seen at this hospital from January 2013 to December 2017 who underwent the ThinPrep cytologic test(TCT)and HPV screening.HPV types were detected in 268 women with an HPV infection in the third trimester of pregnancy.The delivery outcomes of patients with a high-risk or low-risk HPV infection and a healthy control group were compared.All patients were followed up for 2 years to observe a persistent infection with HPV.Logistic regression analysis was used to analyze the independent risk factors for a persistent HPV infection. Results Nine genotypes of HPV were detected in 268 patients with an HPV infection.Of those,229 had a high-risk HPV infection.An HPV16 infection was the most prevalent(39.18%),followed by HPV18(13.80%)and hpv52(13.06%).Thirty-nine patients had a lowrisk HPV infection.HPV6(6.72%)and HPV11(5.97%)were prevalent.Logistic regression analysis indicated that being 20-30 years of age,having thyroid disease,and cervicitis were independent risk factors for a persistent HPV infection(P<0.05).There were no significant differences in the incidence of premature rupture of membranes,premature delivery,neonatal respiratory distress syndrome,or postpartum hemorrhage between the high-risk HPV infection group,low-risk HPV infection group,and healthy control group(P>0.05). Conclusion HPV16 is the main high-risk HPV infection in women in late pregnancy in the City of Chengde.The rate of a persistent infection is high,but there is no direct relationship between HPV infection and pregnancy outcomes.Being 20-30 years of age,having thyroid disease,and cervicitis are risk factors for development of a high-risk HPV infection in late pregnancy.These findings can provide a referen

关 键 词：人类乳头瘤病毒 模式液基薄层细胞学技术 妊娠晚期 HPV感染 独立危险因素 分娩结局 

分 类 号：R373.9[医药卫生—病原生物学]